Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Glutamate neurotoxicity in cortical cell culture

1987 • 1,400 citations

Kainic acid as a tool in neurobiology

1978 • 1,314 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN

1969 • 920 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

1984 • 824 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

1987 • 509 citations

Schizophrenia: Some Current Neurochemical Approaches

1983 • 459 citations

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

1992 • 416 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1991 • 304 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

1989 • 274 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats

1989 • 252 citations

Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3

1989 • 249 citations

Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations.

1978 • 246 citations

Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

1988 • 229 citations

Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration

1986 • 204 citations

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

1992 • 195 citations

Neuronal death in vitro: parallelism between survivability of hippocampal neurones and sustained elevation of cytosolic Ca2+ after exposure to glutamate receptor agonist

1988 • 178 citations

Focal Cortical Seizures Cause Distant Thalamic Lesions

1982 • 172 citations

Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons

1992 • 154 citations

Interleukin 1 pretreatment decreases ischemia/reperfusion injury.

1990 • 152 citations

Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase

1987 • 152 citations

Cellular Origins of Endogenous Amino Acids Released into the Extracellular Fluid of the Rat Striatum During Severe Insulin‐Induced Hypoglycemia

1987 • 130 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains

1992 • 124 citations

Interleukin 6 (IL‐6) and its receptor: Their role in plasma cell neoplasias

1991 • 122 citations

Excitatory Amino Acids and Neuronal Plasticity

1990 • 121 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 94 citations

Amino acid neurotoxicity: Relationship to neuronal depolarization in rat cerebellar slices

1986 • 90 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 85 citations

Localization of cholinergic differentiation factor/leukemia inhibitory factor mRNA in the rat brain and peripheral tissues.

1991 • 83 citations

Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord

1992 • 82 citations

Applications of quantitative measurements for assessing glutamate neurotoxicity.

1988 • 81 citations

Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere

1993 • 73 citations

Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture

1992 • 57 citations

Excitatory Amino Acids, Growth Factors, and Calcium: A Teeter-Totter Model for Neural Plasticity and Degeneration

1990 • 42 citations

In vitro Model of Hypoxia: Basic Fibroblast Growth Factor Can Rescue Cultured CNS Neurons from Oxygen-Deprived Cell Death

1993 • 33 citations

Nerve growth factor promotes survival of retrogradely labeled hippocampus-projecting neurons in the rat basal forebrain in vitro

1989 • 21 citations

Coevolution of cytokine receptor families in the immune and nervous systems

1992 • 14 citations

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