The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

1994 • 373 citations

Enhanced Sensitivity to Oxidative Stress in Cultured Embryonic Cells from Transgenic Mice Deficient in Metallothionein I and II Genes

1995 • 302 citations

Metallothionein III : biological roles and medical implications

1993 • 253 citations

Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

1995 • 250 citations

Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.

1995 • 243 citations

Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin

1992 • 240 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Demonstration of nuclear compartmentalization of glutathione in hepatocytes.

1992 • 220 citations

Enhanced Apoptosis in Metallothionein Null Cells

1997 • 184 citations

Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney

1982 • 182 citations

Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity.

1994 • 166 citations

Direct Reaction of H2O2with Sulfhydryl Groups in HL-60 Cells: Zinc-Metallothionein and Other Sites

1996 • 139 citations

Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells

1988 • 135 citations

Metallothioneins and Cell Death by Anticancer Drugs

1995 • 119 citations

Metallothionein null cells have increased sensitivity to anticancer drugs.

1995 • 116 citations

Copper(I) transfer into metallothionein mediated by glutathione

1993 • 114 citations

Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells.

1997 • 107 citations

Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.

1990 • 96 citations

Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury

1997 • 94 citations

Metallothionein-I and -II Knock-Out Mice Are Sensitive to Cadmium-Induced Liver mRNA Expression of c-junandp53

1996 • 82 citations

A putative glutathione-binding site in CdZn-metallothionein identified by equilibrium binding and molecular-modelling studies

1993 • 81 citations

Metallothionein localization and cisplatin resistance in human hormone-independent prostatic tumor cell lines.

1995 • 69 citations

Covalent Sequestration of Melphalan by Metallothionein and Selective Alkylation of Cysteines

1995 • 48 citations

A Binding Site for Chlorambucil on Metallothionein

1996 • 41 citations

Nucleophilic Distribution of Metallothionein in Human Tumor Cells

1996 • 41 citations

Diversity of metallothionein content and subcellular localization in the National Cancer Institute tumor panel

1997 • 36 citations

Most Nuclear Proteins Are Imported by a Single Pathway

1993 • 35 citations

Annual Review of Pharmacology and Toxicology

1976 • 35 citations

Metallothionein: a protein conferring resistance in vitro to tumor necrosis factor.

1993 • 31 citations

Subcellular Localization of Metallothionein IIA in Human Bladder Tumor Cells Using a Novel Epitope-Specific Antiserum

1994 • 29 citations