Peripheral T Cell Tolerance: Distinct Levels and Multistep Mechanisms

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

1987 • 127 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

Intrathymic presentation of circulating non-major histocompatibility complex antigens

1984 • 102 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.

1988 • 60 citations

A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.

1990 • 50 citations

Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism

1992 • 42 citations

Threshold tolerance in H-2K^b-specific TCR transgenic mice expressing mutant H-2K^b: conversion of helper-independent to helper-dependent CTL

1992 • 24 citations

T cell activation and thymic tolerance induction require different adhesion intensities of the CD8 co-receptor

1992 • 16 citations