Ig-specific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Negative selection of lymphocytes

1994 • 810 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

B Cells Turn Off Virgin But Not Memory T Cells

1992 • 578 citations

Positive selection of lymphocytes

1994 • 563 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

MHC class II—Restricted presentation of intracellular antigen

1991 • 260 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis

1982 • 219 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

Do B cells drive the diversification of immune responses?

1993 • 189 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements

1986 • 151 citations

Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 • 146 citations

THYMECTOMY IN NEWBORN AND ADULT MICE*

1963 • 137 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

A rheumatoid factor transgenic mouse model of autoantibody regulation

1993 • 133 citations

Immunity in Experimental Salmonellosis II. Basis for the Avirulence and Protective Capacity of gal E Mutants of Salmonella typhimurium

1971 • 121 citations

Clonal deletion of specific thymocytes by an immunoglobulin idiotype.

1993 • 100 citations

Weak positive selection of transgenic T cell receptor‐bearing thymocytes: importance of major histocompatibility complex class II, T cell receptor and CD4 surface molecule densities

1992 • 65 citations

Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form.

1988 • 60 citations

Receptor diversity of insulin-specific T cell lines from C57BL (H-2b) mice.

1987 • 50 citations

Immunoglobulin‐specific T‐B cell interaction

1989 • 49 citations

A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice.

1990 • 41 citations

B-cell influences on the induction of allotype suppressor T cells

1979 • 41 citations

Presentation of endogenous immunoglobulin determinant to immunoglobulin‐recognizing T cell clones by the thymic cells

1990 • 30 citations

Presentation of igg2a antigens to class ii‐restricted t cells by stably transfected b lymphoma cells

1989 • 29 citations

Igh-1b-specific CD4+CD8− T cell clones of the Th1 subset selectively suppress the Igh-1b allotypein vivo

1991 • 23 citations

Normal T splenocytes are able to induce immunoglobulin allotypic suppression in F₁ hybrid mice

1987 • 17 citations

Th1 clones that suppress IgG2a^b specifically recognize an allopeptide determinant comprising residues 435–451 of γ2a^b

1993 • 17 citations