Functions of fibroblast growth factors in vertebrate development

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

1996 • 1,952 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

PTH/PTHrP Receptor in Early Development and Indian Hedgehog—Regulated Bone Growth

1996 • 1,303 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

1994 • 1,138 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

1995 • 908 citations

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1994 • 903 citations

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

1996 • 867 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Heparin Structure and Interactions with Basic Fibroblast Growth Factor

1996 • 789 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome

1994 • 759 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

Midbrain development induced by FGF8 in the chick embryo

1996 • 734 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

1994 • 617 citations

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

1995 • 602 citations

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

1994 • 594 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

1994 • 575 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

1993 • 542 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia

1996 • 500 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2

1994 • 466 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development

1996 • 440 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate Proteoglycan

1993 • 420 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans

1995 • 389 citations

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

1991 • 386 citations

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

1996 • 385 citations

Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

1996 • 385 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

FGF-4 and BMP-2 have opposite effects on limb growth

1993 • 377 citations

Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.

1995 • 365 citations

Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en

1991 • 339 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 335 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Differential Splicing in the Extracellular Region of Fibroblast Growth Factor Receptor 1 Generates Receptor Variants with Different Ligand-Binding Specificities

1992 • 321 citations

Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: Dorsal signals regulate anteroposterior patterning

1995 • 318 citations

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 314 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth

1995 • 303 citations

Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia.

1996 • 302 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

Expression of a novel FGF in theXenopusembryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification

1992 • 291 citations

Caudalization of neural fate by tissue recombination and bFGF

1995 • 290 citations

Structure and Expression of the Rat mRNA Encoding a Novel Member of the Fibroblast Growth Factor Family

1996 • 285 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

1995 • 277 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

FGF Binding and FGF Receptor Activation by Synthetic Heparan-Derived Di- and Trisaccharides

1995 • 270 citations

Expression of the fibroblast growth factor-5 gene in the mouse embryo

1991 • 264 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system

1994 • 246 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome

1995 • 233 citations

FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse

1991 • 232 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Dual mode of signal transduction by externally added acidic fibroblast growth factor

1994 • 223 citations

Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice

1995 • 222 citations

The fibroblast growth factor family.

1990 • 219 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1994 • 214 citations

Of Worms and Men: An Evolutionary Perspective on the Fibroblast Growth Factor (FGF) and FGF Receptor Families

1997 • 211 citations

Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

1995 • 211 citations

bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus

1995 • 203 citations

Patterning of the Embryonic Avian Midbrain after Experimental Inversions: A Polarizing Activity from the Isthmus

1994 • 201 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.

1992 • 195 citations

Ligand-induced transphosphorylation between different FGF receptors.

1991 • 189 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

1995 • 186 citations

Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

1992 • 185 citations

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

1995 • 176 citations

The initiation of the limb bud: Growth factors, Hox genes, and retinoids

1995 • 170 citations

A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth

1995 • 168 citations

Control by fibroblast growth factor of differentiation in the BC3H1 muscle cell line.

1985 • 166 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Induction of Lens Fibre Differentiation by Acidic and Basic Fibroblast Growth Factor (FGF)

1989 • 155 citations

Vertebrate limb development

1995 • 154 citations

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

1995 • 154 citations

Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo

1992 • 153 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers

1995 • 146 citations

The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development

1995 • 146 citations

Distribution of FGF‐2 suggests it has a role in chick limb bud growth

1993 • 144 citations

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis

1995 • 142 citations

Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1

1994 • 142 citations

Promiscuity of fibroblast growth factor receptors

1996 • 140 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

1994 • 136 citations

Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by mesodermal and neural induction

1992 • 136 citations

Mutations in the third immunoglobulin domain of the fibroblast growth factor receptor-2 gene in Crouzon syndrome

1995 • 136 citations

Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon

1992 • 134 citations

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

1993 • 132 citations

Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons

1993 • 132 citations

A common FGFR3 gene mutation in hypochondroplasia

1995 • 132 citations

Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb

1996 • 130 citations

Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo

1993 • 130 citations

Fibroblast growth factor receptors display both common and distinct signaling pathways.

1995 • 125 citations

Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.

1995 • 119 citations

The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions

1996 • 116 citations

Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells

1995 • 114 citations

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation

1996 • 103 citations

Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras.

1996 • 102 citations

A novel form of FGF receptor‐3 using an alternative exon in the immunoglobulin domain III

1993 • 99 citations

Stimulation of Proliferation of a Human Osteosarcoma Cell Line by Exogenous Acidic Fibroblast Growth Factor Requires both Activation of Receptor Tyrosine Kinase and Growth Factor Internalization

1996 • 97 citations

Heparin can activate a receptor tyrosine kinase.

1995 • 96 citations

Determination events in the nervous system of the vertebrate embryo

1995 • 93 citations

Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats

1995 • 80 citations

Expression of two different forms of fibroblast growth factor receptor 1 in different mouse tissues and cell lines.

1991 • 75 citations

The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′ HoxD genes during limb pattern formation

1995 • 72 citations

Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of gf-4 and shh in the limb bud

1995 • 67 citations

Murine FGF-4 gene expression is spatially restricted within embryonic skeletal muscle and other tissues

1993 • 53 citations

High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF.

1991 • 52 citations

Differential stability of expression of similarly specified endogenous and exogenous genes in the sea urchin embryo

1991 • 51 citations

A common FGFR3 gene mutation is present in achondroplasia but not in hypochondroplasia

1995 • 46 citations

Expression of Fibroblast Growth Factor Receptor-2 Splice Variants is Developmentally and Tissue-Specifically Regulated in the Amphibian Embryo

1994 • 37 citations