Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors

1983 • 327 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Complete nucleotide sequence of a milk-transmitted mouse mammary tumor virus: two frameshift suppression events are required for translation of gag and pol

1987 • 258 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors

1987 • 203 citations

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

1991 • 192 citations

Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

1990 • 188 citations

Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.

1992 • 155 citations

Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice

1989 • 141 citations

Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus

1986 • 137 citations

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

1993 • 132 citations

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.

1992 • 128 citations

Diversification of the Wnt gene family on the ancestral lineage of vertebrates.

1992 • 127 citations

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene.

1985 • 110 citations

Construction of a clonable, infectious, and tumorigenic mouse mammary tumor virus provirus and a derivative genetic vector.

1988 • 93 citations

Activation of cellular gene by mouse mammary tumour virus may occur early in mammary tumour development

1984 • 70 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family.

1992 • 51 citations

Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumors.

1992 • 42 citations

Expression of Wnt10a in the Central Nervous System of Developing Zebrafish

1993 • 41 citations

Transgenes Expressing the Wnt-1 and int-2 Proto-Oncogenes Cooperate during Mammary Carcinogenesis in Doubly Transgenic Mice

1992 • 40 citations

Isolation and Genetic Mapping of Two Novel Members of the Murine Wnt Gene Family, Wnt11 and Wnt12, and the Mapping of Wnt5a and Wnt7a

1994 • 31 citations

Insertion mutation of the int-1 and int-2 loci by mouse mammary tumor virus in premalignant and malignant neoplasms from the GR mouse strain

1990 • 31 citations

Host genetic background effect on the frequency of mouse mammary tumor virus-induced rearrangements of the int-1 and int-2 loci in mouse mammary tumors

1991 • 28 citations

Nucleotide Sequence and Expression In Vitro of cDNA Derived from mRNA of int-1, a Provirally Activated Mouse Mammary Oncogene

1985 • 27 citations

Mouse mammary-tumor virus activatesFgf-3/Int-2 less frequently in tumors from virgin than from parous mice

1993 • 13 citations