The initiation of the limb bud: Growth factors, Hox genes, and retinoids

Homeobox genes and axial patterning

1992 • 2,688 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Epithelial-Mesenchymal Interactions

1967 • 1,218 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

1982 • 669 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

Experiments on the development of the fore limb of Amblystoma, a self‐differentiating equipotential system

1918 • 330 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures

1994 • 245 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

The effect of local application of retinoic acid to the anterior margin of the developing chick limb

1983 • 210 citations

Vertebrate Limb Development

1994 • 204 citations

Involvement of Androgen-Induced Growth Factor (FGF-8) Gene in Mouse Embryogenesis and Morphogenesis

1994 • 170 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid

1988 • 135 citations

Inductive and axial properties of prospective wing-bud mesoderm in the chick embryo

1974 • 117 citations

Development of fragmented and of dissociated limb bud mesoderm

1964 • 109 citations

Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue.

1990 • 106 citations

Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud

1994 • 97 citations

DEVELOPMENTAL CONTROL OF THREE‐DIMENSIONAL POLARITY IN THE AVIAN LIMB*

1972 • 92 citations

Localization of HstI transcripts to the apical ectodermal ridge in the mouse embryo

1992 • 91 citations

Mechanisms of limb patterning

1994 • 85 citations

Transplantation des OhrblÄschens bei Triton

1925 • 84 citations

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

1991 • 65 citations

The stages of flank ectoderm capable of responding to ridge induction in the chick embryo

1984 • 43 citations