Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

Collagen family of proteins

1991 • 1,243 citations

The Fgf Family of Growth Factors and Oncogenes

1992 • 1,164 citations

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

1994 • 1,138 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia

1994 • 903 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Toward a molecular understanding of skeletal development

1995 • 683 citations

Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S

1980 • 618 citations

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3

1995 • 602 citations

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1992 • 552 citations

FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.

1991 • 541 citations

The ins and outs of fibroblast growth factors

1994 • 535 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

1995 • 464 citations

Unique Expression Pattern of the FGF Receptor 3 Gene during Mouse Organogenesis

1993 • 456 citations

Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation.

1994 • 455 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

Developmental expression of two murine fibroblast growth factor receptors, fig and bek

1991 • 397 citations

The birth prevalence rates for the skeletal dysplasias.

1986 • 379 citations

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

1995 • 370 citations

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

1992 • 330 citations

Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate

1986 • 314 citations

Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1

1994 • 301 citations

Fibroblast-growth-factor receptor mutations in human skeletal disorders

1995 • 300 citations

The BMP proteins in bone formation and repair

1992 • 273 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis.

1987 • 234 citations

FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse

1991 • 232 citations

Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

1992 • 230 citations

Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition

1993 • 213 citations

Achondroplasia and hypochondroplasia. Comments on frequency, mutation rate, and radiological features in skull and spine.

1979 • 179 citations

The DVR gene family in embryonic development

1991 • 159 citations

The DVR gene family in embryonic development

1991 • 84 citations

Observations Suggesting Allelism of the Achondroplasia and Hypochondroplasia Genes

1973 • 71 citations

Activation of glucose transport by a natural mutation in the human insulin receptor.

1993 • 38 citations

Syndrome of proximal interstitial deletion 4p15: Report of three cases and review of the literature

1995 • 34 citations