Chemotherapy Delivery Issues in Central Nervous System Malignancy: A Reality Check

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

2001 • 1,318 citations

Monoclonal antibody therapy of cancer

2005 • 1,209 citations

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

2004 • 1,160 citations

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

2003 • 1,074 citations

Arming antibodies: prospects and challenges for immunoconjugates

2005 • 1,029 citations

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

2004 • 643 citations

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

2004 • 558 citations

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

1997 • 526 citations

A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.

1999 • 491 citations

Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery: Effects of Linker Technology on Efficacy and Toxicity

2005 • 491 citations

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

2004 • 407 citations

Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function.

1991 • 379 citations

Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors

2000 • 378 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 358 citations

The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

2005 • 348 citations

500‐element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls

2004 • 332 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound

2005 • 315 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 312 citations

High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?

1998 • 309 citations

MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits

2005 • 307 citations

Mechanisms of Disease: The Blood-Brain Barrier

2004 • 303 citations

Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux

2002 • 269 citations

Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor.

1999 • 247 citations

Cognitive Outcomes and Long-term Follow-up Results after Enhanced Chemotherapy Delivery for Primary Central Nervous System Lymphoma

2000 • 221 citations

Salvage therapy for primary CNS lymphoma with a combination of rituximab and temozolomide

2004 • 218 citations

Humanization of anti‐human insulin receptor antibody for drug targeting across the human blood–brain barrier

2006 • 192 citations

Comparison of Long-Term Neurocognitive Outcomes in Young Children With Acute Lymphoblastic Leukemia Treated With Cranial Radiation or High-Dose or Very High-Dose Intravenous Methotrexate

2006 • 179 citations

In vivo assessment of the window of barrier opening after osmotic blood—brain barrier disruption in humans

2000 • 164 citations

Imaging, Distribution, and Toxicity of Superparamagnetic Iron Oxide Magnetic Resonance Nanoparticles in the Rat Brain and Intracerebral Tumor

2005 • 163 citations

Imaging, Distribution, and Toxicity of Superparamagnetic Iron Oxide Magnetic Resonance Nanoparticles in the Rat Brain and Intracerebral Tumor

2005 • 155 citations

Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

1999 • 153 citations

Effect of dose and schedule on pharmacokinetics of high-dose cytosine arabinoside in plasma and cerebrospinal fluid.

1983 • 146 citations

Plasma and cerebrospinal fluid pharmacokinetics of intravenous temozolomide in non-human primates.

2003 • 142 citations

CNS prophylaxis in lymphoma: Who to target and what therapy to use

2006 • 140 citations

Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa.

1989 • 136 citations

Pharmacokinetics of high-dose busulfan in children

1989 • 131 citations

Model Selection in Magnetic Resonance Imaging Measurements of Vascular Permeability: Gadomer in a 9L Model of Rat Cerebral Tumor

2005 • 127 citations

Enhanced Prospects for Drug Delivery and Brain Targeting by the Choroid Plexus–CSF Route

2005 • 126 citations

Non-AIDS primary CNS lymphoma: first example of a durable response in a primary brain tumor using enhanced chemotherapy delivery without cognitive loss and without radiotherapy.

1996 • 124 citations

Tight‐Junctional Modification as the Basis of Osmotic Opening of the Blood‐Brain Barriera

1986 • 120 citations

Immunochemotherapy with rituximab and temozolomide for central nervous system lymphomas

2004 • 119 citations

Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein

2004 • 116 citations

Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer

2006 • 113 citations

Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice

1994 • 111 citations

Plasma pharmacokinetics and cerebrospinal fluid concentrations of idarubicin and idarubicinol in pediatric leukemia patients: a Childrens Cancer Study Group report.

1990 • 110 citations

A Review of Blood–Brain Barrier Transport Techniques

2003 • 110 citations

Delivery of β-Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor

2005 • 108 citations

Pharmacokinetics Following Intraventricular Administration of Chemotherapy in Patients with Neoplastic Meningitis

2005 • 105 citations

Monitoring of Methotrexate Delivery in Patients with Malignant Brain Tumors After Osmotic Blood-Brain Barrier Disruption

1981 • 104 citations

Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat

1990 • 98 citations

Pharmacology and toxicity of intracarotid adriamycin administration following osmotic blood-brain barrier modification.

1981 • 96 citations

Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

2004 • 95 citations

Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis

2000 • 93 citations

Effect of Osmotic Blood-Brain Barrier Disruption on Methotrexate Pharmacokinetics in the Dog

1980 • 90 citations

Detoxification systems, passive and specific transport for drugs at the blood?CSF barrier in normal and pathological situations

2004 • 87 citations

Penetration of intra-arterially administered vincristine in experimental brain tumor

2004 • 85 citations

Plasma and Cerebrospinal Fluid Pharmacokinetics of Intravenous Oxaliplatin, Cisplatin, and Carboplatin in Nonhuman Primates

2005 • 82 citations

Comparison of cytosine arabinoside delivery to rat brain by intravenous, intrathecal, intraventricular and intraparenchymal routes of administration

2000 • 82 citations

Pharmacokinetics of intraventricular and intravenous N,N',N''-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans.

1986 • 80 citations

Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk‐stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172)

2003 • 79 citations

Association of Total Dose Intensity of Chemotherapy in Primary Central Nervous System Lymphoma (Human Non-Acquired Immunodeficiency Syndrome) and Survival

2001 • 69 citations

Convection enhanced delivery for the treatment of malignant gliomas: symposium review

2005 • 67 citations

Defining the Appropriate Dosage of Folinic Acid After High-Dose Methotrexate for Childhood Acute Lymphatic Leukemia That Will Prevent Neurotoxicity Without Rescuing Malignant Cells in the Central Nervous System

2004 • 67 citations

Etoposide achieves potentially cytotoxic concentrations in CSF of children with acute lymphoblastic leukemia.

1996 • 66 citations

Role of Site-Specific Binding to Plasma Albumin in Drug Availability to Brain

2006 • 66 citations

Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors

2006 • 64 citations

The Influence of Anesthetic Choice, PaCO2, and Other Factors on Osmotic Blood-Brain Barrier Disruption in Rats with Brain Tumor Xenografts

1999 • 62 citations

Cerebrospinal fluid concentrations of vincristine after bolus intravenous dosing

2002 • 61 citations

Pharmacokinetics of methotrexate in cerebrospinal fluid and serum after osmotic blood-brain barrier disruption in patients with brain lymphoma

2000 • 60 citations

Therapeutic implications of tumor interstitial fluid pressure in subcutaneous RG-2 tumors

2006 • 58 citations

Pharmacology and neurotoxicity of cis-diamminedichloroplatinum, bleomycin, 5-fluorouracil, and cyclophosphamide administration following osmotic blood-brain barrier modification.

1983 • 58 citations

Bone Marrow Chemoprotection without Compromise of Chemotherapy Efficacy in a Rat Brain Tumor Model

2004 • 57 citations

Pharmacokinetics of methotrexate following intravenous and intraventricular administration in acute lymphocytic leukemia and non-Hodgkin's lymphoma

1982 • 56 citations

Enhanced Delivery Improves the Efficacy of a Tumor-specific Doxorubicin Immunoconjugate in a Human Brain Tumor Xenograft Model

2000 • 55 citations

Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children.

1997 • 52 citations

Liposomal cytarabine (DepoCyte®) for the treatment of neoplastic meningitis

2005 • 51 citations

Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat

1990 • 49 citations

Plasma and cerebrospinal fluid pharmacokinetics of cytosine arabinoside in dogs

1991 • 48 citations

Targeted Toxin Therapy for Malignant Astrocytoma

2000 • 47 citations

The Influence of Anesthetic Choice, PaCO2, and Other Factors on Osmotic Blood-Brain Barrier Disruption in Rats with Brain Tumor Xenografts

1999 • 46 citations

Effect of blood-brain barrier disruption on intact and fragmented monoclonal antibody localization in intracerebral lung carcinoma xenografts.

1994 • 45 citations

Chemotherapeutic Agent Permeability to Normal Brain and Delivery to Avian Sarcoma Virus-induced Brain Tumors in the Rodent: Observations on Problems of Drug Delivery

1984 • 45 citations

Central nervous system pharmacokinetics of high-dose cytosine arabinoside

1985 • 44 citations

In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry

2000 • 42 citations

Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

2000 • 42 citations

Methotrexate Concentration Levels in the Cerebrospinal Fluid During High-Dose Methotrexate Infusions: An Unreliable Prediction

1988 • 42 citations

Imaging of central nervous system lymphomas with iodine‐123 labeled rituximab

2005 • 41 citations

The effect of dexamethasone on the uptake of cisplatin in 9L glioma and the area of brain around tumor.

1998 • 40 citations

Cisplatin and radiation in the treatment of tumors of the central nervous system: pharmacological considerations and results of early studies

1994 • 39 citations

Differential permeability of a human brain tumor xenograft in the nude rat: impact of tumor size and method of administration on optimizing delivery of biologically diverse agents.

1998 • 38 citations

Difference in CDDP penetration into CSF between selective intraarterial chemotherapy in patients with malignant glioma and intravenous or intracarotid administration in patients with metastatic brain tumor

1996 • 37 citations

Cerebrospinal Fluid Drug Levels of Leukemic Children Receiving Intravenous 5 g/m²Methotrexate

1994 • 36 citations

Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside

1992 • 35 citations

In vivo distribution of [11C]-busulfan incynomolgus monkey and in the brain of a human patient

1992 • 34 citations

Effect of dose and repeat intravenous 24 hr infusions of methotrexate on cerebrospinal fluid availability in children with hematological malignancies

1987 • 31 citations

Plasma pharmacokinetics and tissue distribution of thiotepa in mice.

1984 • 31 citations

Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas

2006 • 31 citations

Differential permeability and quantitative MR imaging of a human lung carcinoma brain xenograft in the nude rat.

1995 • 30 citations

Severe complications after intrathecal methotrexate (MTX) for treatment of primary central nervous system lymphoma (PCNSL)

2003 • 29 citations

Brain metastases in HER2-overexpressing metastatic breast cancer: Comparative analysis of trastuzumab levels in serum and cerebrospinal fluid

2006 • 28 citations

Factors affecting platinum concentrations in human surgical tumour specimens after cisplatin

1995 • 28 citations

CSF drug levels for children with acute lymphoblastic leukemia treated by 5 g/m2 methotrexate

1990 • 28 citations

Penetration of idarubicin into malignant brain tumor tissue.

1999 • 27 citations

The accumulation of topotecan in 9L glioma and in brain parenchyma with and without dexamethasone administration.

1999 • 26 citations

Influence of schedule of administration on methotrexate penetration in brain tumours

2000 • 25 citations

The Choroid Plexus-CSF Nexus: Gateway to the Brain

2003 • 24 citations

Concentrations of VP16 and VM26 in human brain tumors

1991 • 24 citations

Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma

2005 • 22 citations

5-fluorouracil, leucovorin, hydroxyurea, and escalating doses of continuous-infusion cisplatin with concomitant radiotherapy: a clinical and pharmacologic study

1992 • 21 citations

Isolation of drug delivery from drug effect: Problems of optimizing drug delivery parameters1

2006 • 21 citations

Distribution and pharmacokinetics of cyclophosphamide in the rat

1980 • 20 citations

Long-term Toxicity and Neuropathology Associated with the Sequencing of Cranial Irradiation and Enhanced Chemotherapy Delivery

1997 • 19 citations

Management of relapse and survival in advanced stage Hodgkin's disease: The EORTC experience

1991 • 18 citations

Cis-diamminedichloroplatinum (CDDP) therapy for brain metastasis of lung cancer

1993 • 18 citations

Pharmacokinetics of 7‐Hydroxy‐methotrexate and Methotrexate in the Rat

1988 • 18 citations

Interaction between route of intra-CSF chemotherapy administration and efficacy of therapy in patients wtih neoplastic meningitis

2006 • 15 citations

The Effect of Enzyme-Inducing Antiseizure Drugs on the Pharmacokinetics and Tolerability of Procarbazine Hydrochloride

2006 • 14 citations

Fluorescein-methotrexate transport in dogfish shark (Squalus acanthias) choroid plexus

2006 • 14 citations

Comparison of CNS Penetration, Tissue Distribution, and Pharmacology of VP 16–213 by Intracarotid and Intravenous Administration in Dogs

1987 • 13 citations

Transcranial MRI-guided focused ultrasound-induced blood-brain barrier opening in rats

2005 • 12 citations

Differences in the distribution of methotrexate into high grade gliomas following intravenous administration, as monitored by microdialysis, are associated with blood brain barrier integrity

2006 • 10 citations

Pharmacological study of modified intermediate-dose cytarabine therapy in patients with acute myeloid leukemia.

2004 • 8 citations

The Choroid Plexus—CSF Nexus

2003 • 7 citations

Safety and Efficacy of a Multi-Center Study using Intraarterial Chemotherapy in Conjunction with Osmotic Opening of the Blood-Brain Barrier for the Treatment of Malignant Brain Tumors

1999 • 6 citations

Association of Total Dose Intensity of Chemotherapy in Primary Central Nervous System Lymphoma (Human Non-Acquired Immunodeficiency Syndrome) and Survival

2001 • 6 citations