A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.

The Functional Assessment of Cancer Therapy scale: development and validation of the general measure.

1993 • 5,539 citations

Diagnosis and treatment of leptomeningeal metastases from solid tumors: Experience with 90 patients

1982 • 1,100 citations

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

1975 • 676 citations

Intracranial metastases from systemic cancer.

1978 • 621 citations

CNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survival

1979 • 478 citations

Malignant cells in cerebrospinal fluid (CSF)

1979 • 471 citations

Cerebrospinal fluid cytology in patients with cancer

1998 • 431 citations

Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis

1995 • 402 citations

Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group.

1993 • 351 citations

A prospective randomized trial of single-agent versus combination chemotherapy in meningeal carcinomatosis.

1987 • 337 citations

Leptomeningeal Carcinomatosis

1996 • 283 citations

Cytarabine and neurologic toxicity.

1991 • 264 citations

Leptomeningeal metastasis

1990 • 259 citations

Subarachnoid Distribution of Drugs after Lumbar Injection

1962 • 217 citations

Dose schedule and antitumor studies of arabinosyl cytosine (NSC 63878).

1969 • 216 citations

Meningeal carcinomatosis in breast cancer. Prognostic factors and influence of treatment

1991 • 204 citations

Meningeal carcinomatosis in breast cancer

1978 • 192 citations

Diagnosis, management, and survival of patients with leptomeningeal cancer based on cerebrospinal fluid-flow status

1995 • 185 citations

Carcinomatous Leptomeningitis in Small Cell Lung Cancer

1982 • 170 citations

Treatment of meningeal neoplasms.

1977 • 160 citations

Cerebrospinal fluid flow abnormalities in patients with neoplastic meningitis

1982 • 156 citations

Extended CSF cytarabine exposure following intrathecal administration of DTC 101.

1993 • 153 citations

Prognostic significance of sup 111 Indium-DTPA CSF flow studies in leptomeningeal metastases

1996 • 149 citations

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

1978 • 149 citations

Leptomeningeal metastases from solid tumors: a comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy.

1998 • 148 citations

Central Nervous System Pharmacology of Antileukemic Drugs

1989 • 144 citations

Cytosine arabinoside cerebrospinal fluid kinetics

1984 • 140 citations

Meningeal carcinomatosis in patients with breast carcinoma: Clinical features, prognostic factors, and results of a high-dose intrathecal methotrexate regimen

1996 • 135 citations

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab?)2-a preliminary report

1995 • 128 citations

Adverse effects of intrathecal methotrexate in children with acute leukemia in remission.

1975 • 126 citations

Leptomeningeal metastases

1991 • 126 citations

Combination intraventricular chemotherapy for meningeal neoplasia.

1986 • 120 citations

Carcinomatous meningitis in patients with breast cancer. An aggressive disease variant

1994 • 117 citations

Central nervous system progression of metastatic breast cancer in patients treated with paclitaxel

1995 • 112 citations

Intraventricular versus intralumbar methotrexate for central‐nervous‐system leukemia: Prolonged remission with the ommaya reservoir

1979 • 107 citations

Clinical Outcome in Aggressively Treated Meningeal Carcinomatosis

1994 • 98 citations

In vitro pharmacodynamics of 1-beta-D-arabinofuranosylcytosine: synergy of antitumor activity with cis-diamminedichloroplatinum(II).

1988 • 88 citations

Optic Atrophy Following Prophylactic Chemotherapy and Cranial Radiation for Acute Lymphocytic Leukemia

1976 • 87 citations

Prognostic Significance of Coexistent Bulky Metastatic Central Nervous System Disease in Patients With Leptomeningeal Metastases

1997 • 87 citations

Pharmacokinetics of Intralumbar DTC-101 for the Treatment of Leptomeningeal Metastases

1995 • 84 citations

Comparison of cisternal and lumbar CSF examination in leptomeningeal metastasis

1992 • 82 citations

Pharmacokinetics of intraventricular and intravenous N,N',N''-triethylenethiophosphoramide (thiotepa) in rhesus monkeys and humans.

1986 • 80 citations

Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

1996 • 80 citations

Whole brain irradiation and intrathecal Methotrexate in the treatment of solid tumor leptomeningeal metastases — A Southwest Oncology Group study

1988 • 78 citations

Neoplastic meningitis

1983 • 70 citations

Multivesicular liposomes containing 1-beta-D-arabinofuranosylcytosine for slow-release intrathecal therapy.

1987 • 63 citations

Leptomeningeal cancer in leukemia and solid tumors

1988 • 63 citations

Phase I/II trial and pharmacokinetics of intrathecal diaziquone in refractory meningeal malignancies.

1992 • 59 citations

Prolongation of drug exposure in cerebrospinal fluid by encapsulation into DepoFoam.

1993 • 58 citations

Treatment of neoplastic meningitis with intraventricular thiotepa and methotrexate.

1982 • 57 citations

Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type

1993 • 56 citations

Early blindness and coma during intrathecal chemotherapy for meningeal carcinomatosis

1990 • 42 citations

The influence of previous lumbar puncture and pneumoencephalography on the incidence of unsuccessful radioisotope cisternography.

1971 • 41 citations

Intrathecal 6-mercaptopurine: preclinical pharmacology, phase I/II trial, and pharmacokinetic study.

1991 • 39 citations

New approaches to and current treatment of leptomeningeal metastases

1994 • 37 citations

Leptomeningeal metastases--treatment results in 98 consecutive patients.

1988 • 36 citations

Cellular and clinical pharmacology of low-dose ara-C.

1985 • 27 citations

Cytosine Arabinoside (NSC 63878) Toxicity and Antitumor Activity in Human Solid Tumors

1974 • 26 citations

Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing.

1989 • 21 citations