Role of Site-Specific Binding to Plasma Albumin in Drug Availability to Brain

Goodman & Gilman's The Pharmacological Basis of Therapeutics

1985 • 7,054 citations

All About Albumin: Biochemistry, Genetics, and Medical Applications

1995 • 3,060 citations

The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

2005 • 2,454 citations

The characterization of two specific drug binding sites on human serum albumin.

1975 • 1,586 citations

Practical Aspects of the Ligand-Binding and Enzymatic Properties of Human Serum Albumin.

2002 • 833 citations

Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin

2001 • 779 citations

An in situ brain perfusion technique to study cerebrovascular transport in the rat

1984 • 538 citations

Predicting plasma protein binding of drugs: a new approach

2002 • 528 citations

Binding of drugs to human serum albumin:XI. The specificity of three binding sites as studied with albumin immobilized in microparticles.

1979 • 446 citations

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

1978 • 444 citations

Structural and functional aspects of the blood-brain barrier

2003 • 423 citations

Chiral Separation Mechanisms in Protein-Based HPLC Columns. 1. Thermodynamic Studies of (R)- and (S)-Warfarin Binding to Immobilized Human Serum Albumin

1994 • 279 citations

Species differences of serum albumins: I. Drug binding sites.

1997 • 274 citations

Brain Drug Targeting: The Future of Brain Drug Development

2001 • 153 citations

Equilibrium dialysis, ultrafiltration, and ultracentrifugation compared for determining the plasma-protein-binding characteristics of valproic acid.

1985 • 142 citations

Characterization of an important drug binding area on human serum albumin including the high-affinity binding sites of warfarin and azapropazone.

1982 • 133 citations

Tracer kinetic model of blood-brain barrier transport of plasma protein-bound ligands. Empiric testing of the free hormone hypothesis.

1984 • 125 citations

Brain Drug Targeting

2001 • 113 citations

Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System

1996 • 112 citations

A Review of Blood–Brain Barrier Transport Techniques

2003 • 110 citations

Determination of Drug−Plasma Protein Binding Kinetics and Equilibria by Chromatographic Profiling: Exemplification of the Method Using <scp>l</scp>-Tryptophan and Albumin

2001 • 102 citations

Fatty Acid Uptake and Incorporation in Brain: Studies with the Perfusion Model

2001 • 96 citations

Effect of mobile phase composition on the binding kinetics of chiral solutes on a protein-based high-performance liquid chromatography column:

1997 • 93 citations

Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation.

1989 • 92 citations

Changes in Brain Capillary Diameter during Hypocapnia and Hypercapnia

1993 • 91 citations

Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

1988 • 85 citations

Drug-protein binding and blood-brain barrier permeability.

1999 • 74 citations

Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.

1996 • 72 citations

Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats.

1990 • 42 citations

Determination of Free Valproic Acid Concentrations Using the Amicon Micropartition MPS-1 Ultrafiltration System

1985 • 26 citations

Tracer Kinetic Model of Blood-Brain Barrier Transport of Plasma Protein-bound Ligands

1984 • 24 citations

Effect of plasma protein binding on kinetics of capillary uptake and efflux.

1993 • 21 citations

Brain Uptake of L‐Tryptophan and Diazepam: The Role of Plasma Protein Binding

1989 • 19 citations

MEASUREMENT OF BLOOD‐BRAIN BARRIER PERMEABILITY

1990 • 15 citations

Comparative warfarin binding to albumin from various species

1977 • 13 citations

No Evidence for In Vivo Enhanced Dissociation

1989 • 9 citations

Blood—Brain Barrier Transport and Protein Binding of Flumazenil and Iomazenil in the Rat: Implications for Neuroreceptor Studies

1999 • 9 citations

Effect of alpha-1-acid glycoprotein, albumin and palmitic acid on the brain and salivary gland extraction of warfarin in rats.

1989 • 7 citations