Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat

Simultaneous Statistical Inference

1981 • 5,665 citations

An in situ brain perfusion technique to study cerebrovascular transport in the rat

1984 • 538 citations

Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier

1987 • 441 citations

Anticancer agents based on natural product models

1980 • 411 citations

Cancer chemotherapy handbook

1980 • 283 citations

Neurotoxicity of antineoplastic drugs.

1982 • 231 citations

Chemotherapy of cancer

1977 • 224 citations

Cancer Chemotherapy Handbook

1981 • 141 citations

Pharmacokinetics and metabolism of vinblastine in humans.

1977 • 126 citations

Optimizing drug delivery to brain tumors

1987 • 118 citations

Comparative pharmacokinetics of vindesine, vincristine and vinblastine in patients with cancer

1980 • 105 citations

The pharmacokinetics of [₃H]‐vincristine in man

1977 • 105 citations

Restrictive Transport of a Lipid‐Soluble Peptide (Cyclosporin) Through the Blood–Brain Barrier

1985 • 100 citations

Randomized Trials in Cancer: A Critical Review by Sites

1986 • 91 citations

Pharmacokinetics of anticancer agents in humans

1983 • 91 citations

Cytotoxic thresholds of vincristine in a murine and a human leukemia cell line in vitro.

1979 • 90 citations

Chemotherapy of brain metastases: Current status

1984 • 84 citations

Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system.

1987 • 84 citations

Biliary excretion of vincristine

1978 • 83 citations

Response to vincristine of recurrent brain tumors in children

1976 • 82 citations

Phenylalanine Transport Across the Blood‐Brain Barrier as Studied with the In Situ Brain Perfusion Technique

1987 • 77 citations

Drug Delivery to the Brain by Blood-Brain Barrier Circumvention and Drug Modification

1989 • 76 citations

Kinetics of Amino Acid Transport at the Blood‐Brain Barrier Studied Using an in Situ Brain Perfusion Technique

1986 • 72 citations

Pharmacokinetics of vincristine in the cerebrospinal fluid of humans.

1981 • 66 citations

Distribution and excretion of (3H)vincristine in the rat and the dog.

1976 • 61 citations

Interaction of vinblastine, vincristine and colchicine with serum proteins

1973 • 52 citations

Simple Diffusion across the Membrane Bilayer

1986 • 48 citations

Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat

1988 • 46 citations

Distribution and metabolism of vincristine in mice, rats, dogs, and monkeys.

1977 • 46 citations

NEUROTOXICITY OF VINCRISTINE AFTER THE OSMOTIC OPENING OF THE BLOOD‐BRAIN BARRIER

1983 • 44 citations

Some effects of vinblastine implantation in the cerebral white matter.

1970 • 44 citations

Blood-brain barrier integrity and host responses in experimental metastatic brain tumours

1983 • 42 citations

Pharmacokinetics of vincristine infusion.

1981 • 41 citations

Studies on the Chemotherapy of Experimental Brain Tumors: Evaluation of 1-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea, Vineristine and 5-Fluorouracil<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1971 • 34 citations

Melphalan concentration dependent plasma protein binding in healthy humans and rats

1987 • 26 citations

Pharmacokinetics of vincristine in the cerebrospinal fluid of subhuman primates.

1980 • 25 citations

Chemical characterization of the degradation products of vinblastine dihydrogen sulfate.

1985 • 21 citations

Murine neuroblastoma: a model of human disease.

1973 • 18 citations

Structural studies on the degradation products of vincristine dihydrogen sulfate.

1985 • 17 citations

Correlation of the clinical neurotoxicity of the vinca alkaloids vincristine, vinblastine, and vindesine with their effects on cultured rat midbrain cells

1979 • 17 citations

Murine neuroblastoma: further evaluation of the C1300 model with single antitumor agents.

1975 • 16 citations

The protein binding of vinblastine in the serum of normal subjects and patients with Hodgkin's disease

1983 • 15 citations

INTRAARTERIAL CHEMOTHERAPY OF PRIMARY BRAIN TUMORS

1969 • 13 citations

Pharmacokinetics of vincristine, vinblastine, and vindesine in rhesus monkeys

1984 • 12 citations

The Vinca Alkaloids

1979 • 11 citations

Glioma of the brain treated by intravenous vincristine sulphate

1969 • 9 citations

Chemotherapy of cancer, 3rd ed

1987 • 9 citations

Microculture of human brain tumors.

1970 • 9 citations

Vincristine Therapy in Malignant Glioma Recurrencies

1973 • 8 citations