The Effect of Enzyme-Inducing Antiseizure Drugs on the Pharmacokinetics and Tolerability of Procarbazine Hydrochloride

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2005 • 18,835 citations

The jackknife-a review

1974 • 1,426 citations

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

2000 • 940 citations

Practice parameter: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors [RETIRED]

2000 • 834 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group.

1994 • 448 citations

Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarrazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report

1990 • 399 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Randomized Trial of Procarbazine, Lomustine, and Vincristine in the Adjuvant Treatment of High-Grade Astrocytoma: A Medical Research Council Trial

2001 • 319 citations

Induction of CYP2C genes in human hepatocytes in primary culture.

2001 • 316 citations

Phase II Trial of Procarbazine, Lomustine, and Vincristine as Initial Therapy for Patients With Low-Grade Oligodendroglioma or Oligoastrocytoma: Efficacy and Associations With Chromosomal Abnormalities

2003 • 245 citations

Health-Related Quality of Life in Patients Treated With Temozolomide Versus Procarbazine for Recurrent Glioblastoma Multiforme

2000 • 216 citations

REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS

2004 • 176 citations

Practical implementation of a modified continual reassessment method for dose-finding trials

1998 • 164 citations

Procarbazine, Lomustine, and Vincristine (PCV) Chemotherapy for Anaplastic Astrocytoma: A Retrospective Review of Radiation Therapy Oncology Group Protocols Comparing Survival With Carmustine or PCV Adjuvant Chemotherapy

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Common noncompartmental pharmacokinetic variables: are they normally or log-normally distributed?

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Single-Agent Chemotherapy of Brain Tumors

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Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma.

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1994 • 104 citations

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Procarbazine hydrochloride in the treatment of brain tumors

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Drugs Five Years Later

1974 • 96 citations

Phase II study of procarbazine, CCNU, and vincristine combination chemotherapy in the treatment of malignant brain tumors

1975 • 88 citations

Phase III randomized study of postradiotherapy chemotherapy with alpha-difluoromethylornithine-procarbazine, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosurea, vincristine (DFMO-PCV) versus PCV for glioblastoma multiforme.

2000 • 87 citations

Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors

1989 • 83 citations

A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404

1999 • 78 citations

Preparation of mean drug concentration-time curves in plasma. A study on the frequency distribution of pharmacokinetic parameters.

1985 • 59 citations

A role for preirradiation PCV chemotherapy for oligodendroglial brain tumors

2000 • 56 citations

Oxidative metabolism of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine) by rat liver microsomes.

1979 • 53 citations

Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors

1997 • 49 citations

Methane formation in vivo from N-isopropyl α(2-methylhydrazino)-ρ-toluamide hydrochloride, a tumor-inhibiting methylhydrazine derivative

1967 • 47 citations

In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study

1992 • 34 citations

Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells.

1989 • 33 citations

Hypersensitivity reactions to procarbazine with mechlorethamine, vincristine, and procarbazine chemotherapy in the treatment of glioma

1992 • 31 citations

The mitochondrial metabolism of 1,2-disubstituted hydrazines, procarbazine and 1,2-dimethylhydrazine.

1983 • 26 citations

SOME PHARMACOLOGIC PROPERTIES OF A NEW ANTITUMOR AGENT, N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-P-TOLUAMIDE, HYDROCHLORIDE (NSC-77213).

1964 • 26 citations

Drug points: Hepatotoxicity associated with zolpidem treatment

1999 • 25 citations

Demethylation in vivo of natulan, a tumour-inhibiting methylhydrazine derivative

1965 • 22 citations

Chemotherapy of malignant glioma with CCNU alone and CCNU combined with vincristine sulfate and procarbazine hydrochloride.

1976 • 22 citations

Quantitative analysis of procarbazine, procarbazine metabolites and chemical degradation products with application to pharmacokinetic studies

1982 • 21 citations

Methylazoxyprocarbazine, the active metabolite responsible for the anticancer activity of procarbazine against L1210 leukemia.

1989 • 20 citations

Suspected Carbamazepine-Induced Hepatotoxicity

1999 • 19 citations

Phenytoin-induced Toxic Cholestatic Hepatitis in a Patient with Skin Lesions: Case Report

2003 • 19 citations

The in vivo cytotoxic activity of procarbazine and procarbazine metabolites against L1210 ascites leukemia cells in CDF1 mice and the effects of pretreatment with procarbazine, phenobarbital, diphenylhydantoin, and methylprednisolone upon in vivo procarbazine activity

1983 • 19 citations

Distribution and excretion studies of procarbazine in animals and man.

1967 • 18 citations

The potentiation of barbiturate-induced narcosis by procarbazine.

1976 • 18 citations

Effects in vivo of lymphoma ascites tumors and procarbazine, alone and in combination, upon hepatic drugmetabolizing enzymes of mice

1976 • 13 citations

Determination of procarbazine in human plasma by liquid chromatography with electrospray ionization mass spectrometry

2003 • 13 citations

Intensified PCV-chemotherapy with optional stem cell support in recurrent malignant oligodendroglioma

2002 • 6 citations

Inhibition of Hepatic Microsomal Drug Metabolism by the Hydrazines Ro 4-4602, MK 486, and Procarbazine Hydrochloride

1972 • 6 citations