Mechanisms of Disease: The Blood-Brain Barrier

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Multiple Sclerosis

2000 • 2,813 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease

2001 • 2,290 citations

Parkinson's Disease

1998 • 1,953 citations

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

2000 • 1,296 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

TRANSPLANTATION OF EMBRYONIC DOPAMINE NEURONS FOR SEVERE PARKINSON'S DISEASE

2001 • 1,013 citations

The Concept of a Blood-Brain Barrier

1980 • 812 citations

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

2001 • 742 citations

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

1997 • 694 citations

Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means

1998 • 574 citations

An in situ brain perfusion technique to study cerebrovascular transport in the rat

1984 • 538 citations

Obesity

2002 • 532 citations

Treatment of Bacterial Meningitis

1997 • 504 citations

Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration.

2001 • 501 citations

CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

1998 • 436 citations

Transporting therapeutics across the blood-brain barrier

1996 • 429 citations

Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene

2001 • 424 citations

Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.

1998 • 393 citations

Treatment of Acute Ischemic Stroke

2000 • 391 citations

Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

1999 • 367 citations

The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion

1985 • 354 citations

The Blood-Brain Barrier

1986 • 337 citations

Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue—cannula sealing time

1999 • 333 citations

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

2001 • 330 citations

Hematopoietic Stem-Cell Transplantation in Globoid-Cell Leukodystrophy

1998 • 317 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 308 citations

Role of the CNS microvascular pericyte in the blood-brain barrier

1998 • 301 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

Isolation and characterization of human malignant glioma cells from histologically normal brain

1997 • 290 citations

Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria

1999 • 280 citations

Microglial and Astrocyte Chemokines Regulate Monocyte Migration through the Blood-Brain Barrier in Human Immunodeficiency Virus-1 Encephalitis

1999 • 278 citations

Ischemic brain edema

1999 • 278 citations

Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression

2001 • 259 citations

Noninvasive gene targeting to the brain

2000 • 251 citations

Breaking Down Barriers

2002 • 236 citations

Effects of Diets High in Sucrose or Aspartame on The Behavior and Cognitive Performance of Children

1994 • 227 citations

Cognitive Outcomes and Long-term Follow-up Results after Enhanced Chemotherapy Delivery for Primary Central Nervous System Lymphoma

2000 • 221 citations

Matrix metalloproteinases contribute to the blood—brain barrier disruption during bacterial meningitis

1998 • 198 citations

Chemotherapy of Brain Tumors

1977 • 196 citations

Antigen-Dependent Intrathecal Antibody Synthesis in the Normal Rat Brain: Tissue Entry and Local Retention of Antigen-Specific B Cells

1998 • 195 citations

Biodegradable polymer implants to treat brain tumors

2001 • 189 citations

The effects of antihistamines on cognition and performance

2000 • 185 citations

Mechanisms of action of interferons and glatiramer acetate in multiple sclerosis

2002 • 183 citations

Blood-brain barrier breach following cortical contusion in the rat

1996 • 175 citations

Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study

1999 • 168 citations

Matrix metalloproteinases in inflammatory demyelination

1999 • 168 citations

Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier*

2000 • 151 citations

A comparative evaluation of conventional and pretargeted radioimmunotherapy of CD20-expressing lymphoma xenografts

2001 • 149 citations

Comparison of Two Superparamagnetic Viral-Sized Iron Oxide Particles Ferumoxides and Ferumoxtran-10 with a Gadolinium Chelate in Imaging Intracranial Tumors

2002 • 147 citations

HYPERTENSION MECHANISMS CAUSING STROKE

1999 • 145 citations

Introduction to the blood-brain barrier : methodology, biology, and pathology

2006 • 128 citations

Enhanced Neuroprotective Effects of Basic Fibroblast Growth Factor in Regional Brain Ischemia after Conjugation to a Blood-Brain Barrier Delivery Vector

2002 • 125 citations

Interaction ofNeisseria meningitidiswith the Components of the Blood‐Brain Barrier Correlates with an Increased Expression of PilC

1997 • 121 citations

Regulation of Blood-Brain Tumor Barrier Permeability by Calcium-Activated Potassium Channels

2002 • 121 citations

Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain.

1995 • 119 citations

Migration of Multiple Sclerosis Lymphocytes Through Brain Endothelium

2002 • 118 citations

Neutral Amino Acid Transport Characterization of Isolated Luminal and Abluminal Membranes of the Blood-Brain Barrier

1995 • 117 citations

Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma

1991 • 116 citations

Steroid‐induced CT changes in patients with recurrent malignant glioma

1988 • 100 citations

Comparison of 14C-sucrose delivery to the brain by intravenous, intraventricular, and convection-enhanced intracerebral infusion

1999 • 96 citations

Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood–brain barrier without inducing reactive gliosis

1999 • 95 citations

Effects of Clinically Used Antioxidants in Experimental Pneumococcal Meningitis

2000 • 94 citations

First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate.

1998 • 94 citations

Strategies for Increasing Drug Delivery to the Brain

2002 • 76 citations

A physiological barrier distal to the anatomic blood-brain barrier in a model of transvascular delivery.

1999 • 70 citations

Association of Total Dose Intensity of Chemotherapy in Primary Central Nervous System Lymphoma (Human Non-Acquired Immunodeficiency Syndrome) and Survival

2001 • 69 citations

Central Nervous System Relapse of Systemic Non-Hodgkin's Lymphoma: Results of Treatment Based on High-dose Methotrexate Combination Chemotherapy

2002 • 67 citations

Rattlesnake Hunting Behavior: Correlations between Plasticity of Predatory Performance and Neuroanatomy

1998 • 65 citations

Evolution of Diagnostic Neuroradiology from 1904 to 1999

2000 • 58 citations

Microdialysis in the study of drug transporters in the CNS

2000 • 57 citations

Brain-directed gene therapy for lysosomal storage disease: Going well beyond the blood– brain barrier

2002 • 48 citations

Trafficking of superparamagnetic iron oxide particles (Combidex) from brain to lymph nodes in the rat

2003 • 46 citations

Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions

1999 • 45 citations

Effect of steroids on Gd‐enhancing lesions before and during recombinant beta interferon la treatment in relapsing remitting multiple sclerosis

1998 • 44 citations

Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure

2002 • 44 citations

Chemotherapy in the treatment of malignant brain tumors.

1975 • 43 citations

Chemotherapeutic dose intensification for treatment of malignant brain tumors: Recent developments and future directions

2002 • 42 citations

Entry routes of malignant lymphoma into the brain and eyes in a mouse model.

2001 • 42 citations

Importance of dose intensity in neurooncology clinical trials: Summary Report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium

2001 • 30 citations

Endovascular Restorative Neurosurgery: A Novel Concept for Molecular and Cellular Therapy of the Nervous System

2003 • 30 citations

Positron Emission Tomography Shows that Intrathecal Leptin Reaches the Hypothalamus in Baboons

2002 • 28 citations

Postoperative CT contrast enhancement following lobectomy for epilepsy

1990 • 26 citations

Targeted delivery in primary and metastatic brain tumors: summary report of the seventh annual meeting of the Blood-Brain Barrier Disruption Consortium.

2002 • 25 citations

The blood-brain barrier and aids

2001 • 24 citations

Glutamate-containing parenteral nutrition doubles plasma glutamate: A risk factor in neurosurgical patients with blood-brain barrier damage?

1999 • 19 citations

Importance of dose intensity in neurooncology clinical trials: Summary Report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium

2001 • 15 citations

Promising vistas in hydrocephalus and cerebrospinal fluid research

2001 • 11 citations

Cerebrovascular Disease and the Blood-Brain Barrier

1989 • 10 citations

Encephalitogenic lymphoblast recruitment to resting CNS microvasculature: a natural immunosurveillance mechanism?

2001 • 4 citations

Preface

2002 • 1 citations

Deleted Work

1955 • 0 citations