Targeted Toxin Therapy for Malignant Astrocytoma

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

1997 • 526 citations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1988 • 259 citations

Stereotactic radiosurgery for recurrent malignant gliomas.

1995 • 177 citations

Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy

1990 • 177 citations

Immunotoxins and central nervous system neoplasia

1992 • 132 citations

Human neurological cancer cells express interleukin‐4 (IL‐4) receptors which are targets for the toxic effects of IL4‐pseudomonas exotoxin chimeric protein

1994 • 117 citations

Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia

1989 • 111 citations

Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice

1994 • 111 citations

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

1996 • 108 citations

Accumulation of a recombinant immunotoxin in a tumor in vivo: fewer than 1000 molecules per cell are sufficient for complete responses.

1998 • 94 citations

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.

1998 • 92 citations

Intraventricular Immunotoxin Therapy for Leptomeningeal Neoplasia

1997 • 84 citations

Monoclonal antibody-based therapies for hematologic malignancies.

1998 • 82 citations

Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin

1987 • 80 citations

Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma.

1995 • 73 citations

Efficacy of transferrin receptor-targeted immunotoxins in brain tumor cell lines and pediatric brain tumors.

1993 • 71 citations

In vitro efficacy of transferrin-toxin conjugates against glioblastoma multiforme

1992 • 53 citations

Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia

1988 • 51 citations

Epidermal growth factor receptors on ependymomas and other brain tumors

1990 • 47 citations

Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells

1993 • 46 citations

Targeted toxins as anticancer agents

1994 • 46 citations

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

1995 • 43 citations

The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography.

1993 • 37 citations

Potent cytotoxicity of an antihuman transferrin receptor-ricin A-chain immunotoxin on human glioma cells in vitro.

1990 • 35 citations

Pharmacokinetics and toxicology of immunotoxins administered into the subarachnoid space in nonhuman primates and rodents.

1993 • 35 citations

Targeted therapy with immunotoxins in a nude rat model for leptomeningeal growth of human small cell lung cancer.

1994 • 33 citations

In Vivo Efficacy of Intrathecal Transferrin-Pseudomonas Exotoxin A Immunotoxin against LOX Melanoma

1994 • 26 citations

Diphtheria toxin effects on brain-tumor xenografts

1990 • 25 citations

Nude rat models for human tumor metastasis to CNS

1994 • 21 citations

In Vitro and In Vivo Variation in Transferrin Receptor Expression on a Human Medulloblastoma Cell Line

1995 • 18 citations

Advances in Neuro-oncology II

1998 • 14 citations

Rapid Detection of Transferrin Receptor Expression on Glioma Cell Lines by Using Magnetic Microspheres

1993 • 11 citations

Rapid Detection of Transferrin Receptor Expression on Glioma Cell Lines by Using Magnetic Microspheres

1993 • 2 citations