Distinct roles of Central missing and Dispatched in sending the Hedgehog signal

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 • 1,106 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

1998 • 735 citations

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics

2000 • 632 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling

2000 • 477 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily

1990 • 361 citations

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.

1996 • 337 citations

Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway

1997 • 329 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing

1997 • 300 citations

Preferential transposition of Drosophila P elements to nearby chromosomal sites.

1993 • 253 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway

1999 • 207 citations

Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus

2000 • 180 citations

Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye

1997 • 178 citations

Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

1999 • 176 citations

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex

1998 • 173 citations

The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing

1999 • 164 citations

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

2000 • 120 citations

An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development

2001 • 120 citations

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

2001 • 119 citations

Pattern Formation: Hedgehog points the way

1994 • 59 citations

The segment polarity gene costal-2 in Drosophila

1987 • 45 citations

Genetic analysis of chromosome region 63 of Drosophila melanogaster.

1991 • 28 citations