Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced byIn Vivo liver injury in the rat
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
1970 • 253,849 citations
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 • 4,589 citations
STATs and Gene Regulation
1997 • 3,927 citations
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
1995 • 3,456 citations
AP-1 function and regulation
1997 • 2,833 citations
A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
1991 • 2,362 citations
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
1994 • 1,999 citations
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
1995 • 1,960 citations
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies
1993 • 1,444 citations
Regulation of transcription by MAP kinase cascades
1996 • 1,330 citations
Regulation of Cell Motility by Mitogen-activated Protein Kinase
1997 • 1,238 citations
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas
1990 • 1,140 citations
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
1992 • 1,107 citations
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
1997 • 847 citations
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
1994 • 813 citations
Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein
1992 • 772 citations
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.
1990 • 615 citations
Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes
1995 • 578 citations
Platelet-derived growth factor receptor signals.
1994 • 561 citations
Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins
1995 • 549 citations
The search for physiological substrates of MAP and SAP kinases in mammalian cells
1997 • 544 citations
Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.
1989 • 481 citations
The role of extracellular matrix in postinflammatory wound healing and fibrosis
1994 • 415 citations
Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8
1993 • 329 citations
Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
1999 • 307 citations
Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity.
1992 • 284 citations
Cell-free activation of a DNA-binding protein by epidermal growth factor
1993 • 263 citations
Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells
1999 • 259 citations
Molecular regulation of hepatic fibrogenesis
1998 • 249 citations
EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCγ signaling pathway
1998 • 231 citations
Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells
1993 • 230 citations
Mitogen-Activated Protein Kinase Activation Is Involved in Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells
1997 • 219 citations
Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells
1997 • 202 citations
Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride–injured rat liver
1991 • 200 citations
Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases
1997 • 195 citations
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
1998 • 191 citations
Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration
1999 • 171 citations
Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.
1993 • 165 citations
The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.
1997 • 150 citations
Activation of Jun kinase is an early event in hepatic regeneration.
1995 • 150 citations
Expression of platelet-derived growth factor in a model of acute liver injury
1994 • 133 citations
Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells
1997 • 125 citations
Desmin‐containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury
1986 • 122 citations
Lactogenic Hormone Activation of Stat5 and Transcription of the β-Casein Gene in Mammary Epithelial Cells Is Independent of p42 ERK2 Mitogen-activated Protein Kinase Activity
1996 • 108 citations
Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury.
1986 • 108 citations
Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation
1998 • 103 citations
Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells
1999 • 92 citations
Raf and Mitogen-activated Protein Kinase Regulate Stellate Cell Collagen Gene Expression
1996 • 90 citations
Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cells
1995 • 85 citations
Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.
1996 • 76 citations
Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor.
1998 • 56 citations
A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor
1991 • 56 citations
Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes
1998 • 52 citations
Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction
1997 • 46 citations
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