Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

1985 • 839 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

1995 • 536 citations

Collagen Types in Normal and Cirrhotic Liver

1979 • 521 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

1989 • 481 citations

Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and Glycoproteins

1990 • 366 citations

Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers.

1991 • 334 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis

1996 • 289 citations

Fibrogenic effect of oxidative stress on rat hepatic stellate cells

1998 • 281 citations

Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

1992 • 263 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Stimulation of Collagen Formation by Insulin and Insulin-Like Growth Factor I in Cultures of Human Lung Fibroblasts*

1989 • 229 citations

Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells

1997 • 202 citations

HYPERINSULINISM OF HEPATIC CIRRHOSIS: DIMINISHED DEGRADATION OR HYPERSECRETION?

1977 • 201 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

1997 • 196 citations

Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis

1997 • 139 citations

Mechanism of insulin resistance in human liver cirrhosis. Evidence of a combined receptor and postreceptor defect.

1985 • 137 citations

Detection of ERK activation by a novel monoclonal antibody

1997 • 131 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways.

1996 • 113 citations

Transforming growth factor‐β1 induces activation of Ras, Raf‐1, MEK and MAPK in rat hepatic stellate cells

1997 • 104 citations

The Insulin Receptor and Its Substrate: Molecular Determinants of Early Events in Insulin Action

1993 • 92 citations

Raf and Mitogen-activated Protein Kinase Regulate Stellate Cell Collagen Gene Expression

1996 • 90 citations

Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cells

1995 • 85 citations

Insulinlike growth factor I and interleukin 1β messenger RNA in a rat model of granulomatous enterocolitis and hepatitis

1993 • 83 citations

Secretion of Insulin-Like Growth Factor-I and Binding Proteins by Rat Liver Fat-Storing Cells: Regulatory Role of Platelet-Derived Growth Factor*

1990 • 73 citations

Characterization of the IGF axis components in isolated rat hepatic stellate cells

1998 • 67 citations

The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture

1993 • 66 citations

Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells

1995 • 63 citations

IGF-I induces collagen and IGFBP-5 mRNA in rat intestinal smooth muscle

1997 • 63 citations

Neutrophil-mediated phospholipid peroxidation assessed by gas chromatography-mass spectroscopy

1997 • 55 citations

Reduced Requirement of Mitogen-activated Protein Kinase (MAPK) Activity for Entry into the S Phase of the Cell Cycle in Swiss 3T3 Fibroblasts Stimulated by Bombesin and Insulin

1996 • 51 citations

Characterization of ion transport mechanisms regulating intracellular pH in hepatic stellate cells

1997 • 46 citations

Characterization of Insulin-Like Growth Factor (IGF)-I-Receptor Binding Sites during In Vitro Transformation of Rat Hepatic Stellate Cells to Myofibroblasts

1996 • 36 citations

Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells

1992 • 35 citations

Direct Evidence that the Insulin Receptor Mediates a Mitogenic Response in Cultured Human Fibroblasts

1989 • 31 citations

Binding, degradation, and biological activity of insulin in vascular smooth muscle cells

1985 • 20 citations

An Apparent Interlocus Gene Conversion-like Event at a Putative Tumor Suppressor Gene Locus on Human Chromosome 6q27 in a Burkitt's Lymphoma Cell Line

2000 • 11 citations