Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

1989 • 481 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter

1993 • 306 citations

Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

1993 • 285 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens.

1989 • 240 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver.

1994 • 217 citations

Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor.

1994 • 213 citations

Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.

1993 • 197 citations

Inhibition of rat hepatic lipocyte activation in culture by interferon-γ

1992 • 185 citations

Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis.

1991 • 154 citations

Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

1993 • 154 citations

Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver.

1994 • 152 citations

Expression of platelet-derived growth factor in a model of acute liver injury

1994 • 133 citations

The functions of Myc proteins

1992 • 103 citations

Phosphatidylinositol 3-kinase: a novel effector.

1992 • 99 citations

Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells

1993 • 97 citations

Involvement of phosphatidylinositol 3‐kinase in the activation of extracellular signal‐regulated kinase by PDGF in hepatic stellate cells

1995 • 85 citations

Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells

1994 • 67 citations

A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor

1991 • 56 citations

PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells

1994 • 41 citations