Raf and Mitogen-activated Protein Kinase Regulate Stellate Cell Collagen Gene Expression

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8

1993 • 329 citations

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

1994 • 300 citations

Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice.

1995 • 239 citations

Nonparenchymal Cells and Hepatotoxicity

1990 • 167 citations

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1994 • 154 citations

Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

1990 • 150 citations

Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells.

1992 • 134 citations

Regulation of the alpha 1(I) collagen promoter via a transforming growth factor-beta activation element

1993 • 109 citations

Protein Kinase C and Mitogen-activated Protein Kinase Are Required for 1,25-Dihydroxyvitamin D3-stimulated Egr Induction

1995 • 104 citations

Lipoxygenase inhibitors block PDGF-induced mitogenesis: a MAPK-independent mechanism that blocks fos and egr

1995 • 104 citations

Sp1 binding activity increases in activated Ito cells

1995 • 104 citations

An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice.

1991 • 83 citations

Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice.

1994 • 74 citations

Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression

1994 • 74 citations

Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity.

1993 • 69 citations

Analysis of the collagen α(I) promoter

1989 • 64 citations

Regulation of collagen I gene expression by ras.

1992 • 63 citations

Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

1991 • 60 citations

Two different cis-acting regulatory regions direct cell-specific transcription of the collagen alpha 1(I) gene in hepatic stellate cells and in skin and tendon fibroblasts.

1995 • 52 citations

Activation of a serine/threonine kinase signaling pathway by transforming growth factor type beta.

1995 • 34 citations

Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways.

1995 • 21 citations