The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic

Liver Regeneration

1997 • 2,731 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

1996 • 1,498 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli

1996 • 655 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

1996 • 430 citations

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

1997 • 355 citations

Function and evolution in the NGF family and its receptors

1992 • 338 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase

1997 • 237 citations

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1997 • 229 citations

Regulation of signal transduction during liver regeneration

1996 • 228 citations

Growth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro

1996 • 225 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage

1996 • 173 citations

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex.

1993 • 166 citations

Overexpression of ∊-Protein Kinase C Enhances Nerve Growth Factor-induced Phosphorylation of Mitogen-activated Protein Kinases and Neurite Outgrowth

1995 • 143 citations

Protein Kinase C Isozyme-mediated Cell Cycle Arrest Involves Induction of p21 and p27 and Hypophosphorylation of the Retinoblastoma Protein in Intestinal Epithelial Cells

1997 • 143 citations

Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen‐activated protein kinase

1994 • 125 citations

Differential Regulation of the Mitogen-Activated Protein and Stress-Activated Protein Kinase Cascades by Adrenergic Agonists in Quiescent and Regenerating Adult Rat Hepatocytes

1997 • 110 citations

Expression of the c-raf Protooncogene, γ-Glutamyltranspeptidase, and Gap Junction Protein in Rat Liver Neoplasms

1988 • 92 citations

Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism.

1995 • 85 citations

Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

1997 • 84 citations

A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog.

1995 • 82 citations

Local injection of nerve growth factor (NGF) triggers degranulation of mast cells in rat paw

1997 • 81 citations

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

1996 • 56 citations

Differential regulation of Raf isozymes by growth versus differentiation inducing factors in PC12 pheochromocytoma cells

1996 • 51 citations

Time course comparison of cell-cycle protein expression following partial hepatectomy and WY14,643-induced hepatic cell proliferation in F344 rats

1997 • 37 citations

Switching from α1- to β-subtypes in adrenergic response during primary culture of adult-rat hepatocytes as affected by the cell-to-cell interaction through plasma membranes

1994 • 34 citations

Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes*1

1995 • 29 citations

Nerve growth factor and fibroblast growth factor influence post‐fusion expression of Na‐channels in cultured rat skeletal muscle

1990 • 29 citations

Expression of the c-raf protooncogene, gamma-glutamyltranspeptidase, and gap junction protein in rat liver neoplasms.

1988 • 27 citations

Inhibitory Effect of Ethanol on Hepatocyte Growth Factor‐Induced DNA Synthesis and Ca²⁺ Mobilization in Rat Hepatocytes

1996 • 22 citations

Inverse Regulation of Hepatic α_1B‐ and β₂‐Adrenergic Receptors

1995 • 22 citations

Quantification of hepatocytic proliferation in the laboratory mouse

1994 • 13 citations

The v-raf oncogene enhances tumorigenicity and suppresses differentiation in vivo in a rat hepatocyte cell line

1993 • 9 citations

In vitro Regulation of Insulin Release and Biosynthesis of Fetal Rat Pancreatic Cells Explanted on Pregnancy Day 16

1997 • 7 citations

Nerve growth factor binding sites on hepatic parenchymal cells

1992 • 7 citations

Probing the structure-function relationship of nerve growth factor

1992 • 6 citations