The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways

Basic local alignment search tool

1990 • 87,358 citations

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

SMART, a simple modular architecture research tool: Identification of signaling domains

1998 • 3,523 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The PROSITE database, its status in 1997

1997 • 1,783 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Growth of myxamoebae of the cellular slime mould Dictyostelium discoideum in axenic culture

1970 • 1,142 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

The PROSITE database, its status in 1999

1999 • 1,109 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Transport, docking and exocytosis of single secretory granules in live chromaffin cells

1997 • 437 citations

Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells

1995 • 337 citations

Effectors for the Rho GTPases

1999 • 327 citations

SMART: identification and annotation of domains from signalling and extracellular protein sequences

1999 • 325 citations

Modulation of RNA function by aminoglycoside antibiotics

2000 • 312 citations

A flexible motif search technique based on generalized profiles

1996 • 306 citations

Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits.

1991 • 294 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein

1998 • 220 citations

Cloning vectors for the production of proteins in Dictyostelium discoideum

1995 • 206 citations

Increased neutrophil respiratory burst in bcr-null mutants

1995 • 193 citations

Synthesis of GDP-L-fucose by the Human FX Protein

1996 • 163 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Relationship of pseudopod extension to chemotactic hormone‐induced actin polymerization in amoeboid cells

1988 • 161 citations

Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells

2000 • 144 citations

A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis.

1996 • 140 citations

The interaction of Ras with GTPase‐activating proteins

1997 • 133 citations

G Protein β Subunit–null Mutants Are Impaired in Phagocytosis and Chemotaxis Due to Inappropriate Regulation of the Actin Cytoskeleton

1998 • 132 citations

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein

1996 • 125 citations

Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium

2000 • 120 citations

Synaptic-like Microvesicles of Neuroendocrine Cells Originate from a Novel Compartment That Is Continuous with the Plasma Membrane and Devoid of Transferrin Receptor

1997 • 111 citations

Disruption of a Dynamin Homologue Affects Endocytosis, Organelle Morphology, and Cytokinesis inDictyostelium discoideum

1999 • 110 citations

Ethane-Freezing/Methanol-Fixation of Cell Monolayers: A Procedure for Improved Preservation of Structure and Antigenicity for Light and Electron Microscopies

1998 • 99 citations

A Role for Dictyostelium RacE in Cortical Tension and Cleavage Furrow Progression

1998 • 94 citations

Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins

2000 • 93 citations

Overexpression of a Novel Rho Family GTPase, RacC, Induces Unusual Actin-based Structures and Positively Affects Phagocytosis inDictyostelium discoideum

1998 • 90 citations

The Rho GTPases in Macrophage Motility and Chemotaxis

1998 • 85 citations

The contractile vacuole network of Dictyostelium as a distinct organelle: its dynamics visualized by a GFP marker protein

1999 • 80 citations

Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein.

1997 • 75 citations

RacF1, a Novel Member of the Rho Protein Family inDictyostelium discoideum, Associates Transiently with Cell Contact Areas, Macropinosomes, and Phagosomes

1999 • 70 citations

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain

1993 • 70 citations

The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility

1998 • 70 citations

The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.

1993 • 69 citations

Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases

1993 • 68 citations

A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum.

1996 • 66 citations

ABR, an active BCR-related gene

1989 • 39 citations

Modular PH and C2 domains in membrane attachment and other functions

1999 • 33 citations

A flexible search technique based on generalized profiles.

1996 • 28 citations

Comparative analysis of chemotaxis in Dictyostelium using a radial bioassay method: Protein tyrosine kinase activity is required for chemotaxis to folate but not to cAMP

1995 • 25 citations

Cloning and Characterization of a rhoGAP Homolog fromDictyostelium discoideum

1997 • 21 citations

Signalling by Rho family proteins

1997 • 19 citations

Bcr/Abl associated leukemogenesis in bcr null mutant mice

1998 • 15 citations