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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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A tutorial on hidden Markov models and selected applications in speech recognition

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A general method applicable to the search for similarities in the amino acid sequence of two proteins

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A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

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Hidden Markov Models in Computational Biology

1994 • 1,954 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

A time-efficient, linear-space local similarity algorithm

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Computer methods to locate signals in nucleic acid sequences

1984 • 673 citations

Amino acid substitution matrices from an information theoretic perspective

1991 • 637 citations

Determinants of a protein fold

1987 • 498 citations

Escherichia colipromoter sequences predictin vitroRNA polymerase selectivity

1984 • 492 citations

On the Theory and Computation of Evolutionary Distances

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[9] Profile analysis

1990 • 486 citations

Hidden Markov models of biological primary sequence information.

1994 • 465 citations

Mathematical Methods for DNA Sequences.

1990 • 395 citations

Stochastic context-free grammers for tRNA modeling

1994 • 389 citations

The PROSITE dictionary of sites and patterns in proteins, its current status

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Matching Sequences under Deletion/Insertion Constraints

1972 • 301 citations

A new algorithm for best subsequence alignments with application to tRNA-rRNA comparisons

1987 • 293 citations

Secondary structure‐based profiles: Use of structure‐conserving scoring tables in searching protein sequence databases for structural similarities

1991 • 170 citations

Flexible protein sequence patterns

1990 • 120 citations

Improving the sensitivity of the sequence profile method

1994 • 118 citations

[27] Dynamic programming algorithms for biological sequence comparison

1992 • 103 citations

Computer Methods for Analyzing Sequence Recognition of Nucleic Acids

1988 • 102 citations

Weighting aligned protein or nucleic acid sequences to correct for unequal representation

1990 • 95 citations

Some useful statistical properties of position-weight matrices

1994 • 45 citations

An α/gb-barrel full of evolutionary trouble

1993 • 19 citations