Overexpression of a Novel Rho Family GTPase, RacC, Induces Unusual Actin-based Structures and Positively Affects Phagocytosis inDictyostelium discoideum

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

The Dbl family of oncogenes

1996 • 497 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

The Actin Cytoskeleton Is Required for Receptor-mediated Endocytosis in Mammalian Cells

1997 • 394 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

Coronin involved in phagocytosis: Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag

1995 • 353 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Mechanisms of phagocytosis

1996 • 265 citations

Fluid-phase uptake by macropinocytosis in Dictyostelium

1997 • 259 citations

Characterization of RAC3, a Novel Member of the Rho Family

1997 • 240 citations

A Cellophane-Strip Technique for Culturing Tissue in Multipurpose Culture Chambers

1958 • 219 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Rho-related proteins: actin cytoskeleton and cell cycle

1995 • 176 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis.

1996 • 140 citations

Talin-Null Cells of Dictyostelium Are Strongly Defective in Adhesion to Particle and Substrate Surfaces and Slightly Impaired in Cytokinesis

1997 • 138 citations

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

1995 • 125 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Dynamic aspects of filopodial formation by reorganization of microfilaments.

1977 • 116 citations

Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes.

1995 • 110 citations

Kinetics of endosomal pH evolution in Dictyostelium discoideum amoebae Study by fluorescence spectroscopy

1993 • 109 citations

The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

1997 • 107 citations

Inactivation of Two Dictyostelium discoideum Genes, DdPIK1 and DdPIK2, Encoding Proteins Related to Mammalian Phosphatidylinositide 3-kinases, Results in Defects in Endocytosis, Lysosome to Postlysosome Transport, and Actin Cytoskeleton Organization

1997 • 102 citations

Targeted gene disruption reveals a role for vacuolin B in the late endocytic pathway and exocytosis

1998 • 96 citations

Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis

1998 • 91 citations

Functional heterogeneity of monoclonal antibodies obtained using different screening assays

1983 • 89 citations

Induction of gene expression in Dictyostelium by prestarvation factor, a factor secreted by growing cells

1991 • 87 citations

A post-lysosomal compartment in Dictyostelium discoideum.

1993 • 86 citations

Two vectors which facilitate gene manipulation and a simplified transformation procedure for Dictyostelium discoideum

1987 • 86 citations

Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction

1997 • 85 citations

Evidence for a recycling role for Rab7 in regulating a late step in endocytosis and in retention of lysosomal enzymes in Dictyostelium discoideum.

1997 • 79 citations

Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein.

1997 • 75 citations

Role of Acidic Intracellular Compartments in the Biosynthesis of Dictyostelium Lysosomal Enzymes

1989 • 70 citations

Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases

1993 • 68 citations

A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum.

1996 • 66 citations

Endo-lysosomal acidification in Dictyostelium discoideum amoebae. Effects of two endocytosis inhibitors: caffeine and cycloheximide.

1993 • 13 citations

A protein kinase C-like activity involved in the chemotactic response of Dictyostelium discoideum

1997 • 8 citations

Deleted Work

1955 • 0 citations