Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation

1982 • 351 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

1990 • 253 citations

Role of DNA breaks and ADP-ribosyl transferase activity in eukaryotic differentiation demonstrated in human lymphocytes

1982 • 238 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.

1984 • 187 citations

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.

1986 • 175 citations

Molecular biology of DNA methylation

1987 • 166 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

MECHANISMS FOR THE CONTROL OF GENE ACTIVITY DURING DEVELOPMENT

1990 • 153 citations

An estrogen-dependent demethylation at the 5′ end of the chicken vitellogenin gene is independent of DNA synthesis

1984 • 106 citations

Differentiation of two mouse cell lines is associated with hypomethylation of their genomes.

1984 • 96 citations

Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.

1984 • 85 citations

DNA methylation and demethylation events during meiotic prophase in the mouse testis.

1990 • 80 citations

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

1992 • 79 citations

Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.

1991 • 58 citations

Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site

1991 • 54 citations

How Gene Activators Work

1989 • 52 citations

A Laboratory Guide to In Vitro Transcription

1990 • 46 citations

Mycoplasma restriction: identification of a new type of restriction specificity for DNA containing 5-methylcytosine

1986 • 41 citations

Differentiation of Two Mouse Cell Lines Is Associated with Hypomethylation of Their Genomes

1984 • 35 citations

Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells.

1988 • 34 citations

Induction of α-Fetoprotein Synthesis in Differentiating F9 Teratocarcinoma Cells Is Accompanied by a Genome-Wide Loss of DNA Methylation

1984 • 25 citations

A Laboratory Guide to In Vitro Studies of Protein-DNA Interactions

1991 • 20 citations

DNA Methylation and Demethylation Events during Meiotic Prophase in the Mouse Testis

1990 • 17 citations

Protein that induces cell differentiation causes nicks in double‐stranded DNA

1986 • 16 citations

The effect of HhaI methylation on DNA local structure

1986 • 16 citations

DNA hypomethylation and differentiation of Friend erythroleukemia cells

1988 • 2 citations