DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Sequence logos: a new way to display consensus sequences

1990 • 3,249 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Epigenetic mechanisms of gene regulation

1996 • 1,097 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

Hhal methyltransferase flips its target base out of the DNA helix

1994 • 936 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

1986 • 622 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Predictive motifs derived from cytosine methyltransferases

1989 • 505 citations

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

1992 • 454 citations

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

1983 • 404 citations

The somatic replication of DNA methylation

1981 • 368 citations

Creation of genomic methylation patterns

1996 • 313 citations

Loss of methylation activates Xist in somatic but not in embryonic cells.

1995 • 300 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.

1996 • 271 citations

CpNpG methylation in mammalian cells

1995 • 259 citations

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1992 • 250 citations

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1991 • 246 citations

DNA methyltransferases

1994 • 237 citations

Cytosine-specific type II DNA methyltransferases

1989 • 230 citations

DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

1990 • 227 citations

Cloning, characterization, and expression inEscherichia coliof the gene coding for the CpG DNA methylase fromSpiroplasma sp.strain MQ1(M Sssl)

1990 • 214 citations

Protein purification methods: A practical approach

1990 • 191 citations

Enzymatic C5-Cytosine Methylation of DNA: Mechanistic Implications of New Crystal Structures forHhaI Methyltransferase-DNA-AdoHcy Complexes

1996 • 166 citations

Somatically heritable switches in the DNA modification of Mu transposable elements monitored with a suppressible mutant in maize.

1990 • 151 citations

Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation.

1992 • 143 citations

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

1993 • 139 citations

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

1988 • 126 citations

DNA Methylation, Genomic Imprinting, and Mammalian Development

1993 • 108 citations

5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase

1988 • 106 citations

Transcriptional repression by methylation of CpG

1992 • 93 citations

A Structural Basis for the Preferential Binding of Hemimethylated DNA byHhaI DNA Methyltransferase

1996 • 91 citations

Murine DNA Cytosine-C⁵ Methyltransferase: Pre-Steady- and Steady-State Kinetic Analysis with Regulatory DNA Sequences

1996 • 74 citations

Mechanisms of resistance to drugs that inhibit DNA topoisomerases.

1991 • 72 citations

DNA Methylation in Early Mammalian Development

1984 • 65 citations

Primary DNA Sequence Determines Sites of Maintenance and De Novo Methylation by Mammalian DNA Methyltransferases

1986 • 65 citations

The flip side of DNA methylation

1994 • 62 citations

CpG islands in mammalian gene promoters are inherently resistant to de novo methylation

1992 • 59 citations

Expression of Forssman antigen in the post-implantation mouse embryo

1981 • 59 citations

Mutational separation of DNA binding from catalysis in a DNA cytosine methyltransferase

1993 • 55 citations

Supercoiling-dependent sequence specificity of mammalian DNA methyitransferase

1987 • 50 citations

Characterisation of Independent DNA and Multiple Zn-binding Domains at the N Terminus of Human DNA-(Cytosine-5) Methyltransferase: Modulating the Property of a DNA-binding Domain by Contiguous Zn-binding Motifs

1996 • 42 citations

Genetic analysis of genomic methylation patterns in plants and mammals.

1996 • 34 citations

Isolation and Expression of a Chicken DNA Methyltransferase cDNA1

1995 • 33 citations

The sequence specificity of a mammalian DNA methylase

1977 • 30 citations

Isolation of cDNA clones encoding DNA methyltransferase of sea urchin P. lividus: Expression during embryonic development

1996 • 28 citations

De novo and maintenance DNA methylation by a mouse plasmacytoma cell DNA methyltransferase.

1988 • 27 citations

Isolation and Expression of a Xenopus laevis DNA Methyltransferase cDNA

1996 • 25 citations

Specific Effects of 5-Fluoropyrimidines and 5-Azapyrimidines on Modification of the 5 Position of Pyrimidines, in Particular the Synthesis of 5-Methyluracil and 5-Methylcytosine in Nucleic Acids

1983 • 24 citations

Synthesis of an oligonucleotide suicide substrate for DNA methyltransferases

1992 • 22 citations

Non-C-G recognition sequences of DNA cytosin-5-methyltransferase from rat liver

1989 • 19 citations

The Primary DNA Sequence Determines in Vitro Methylation by Mammalian DNA Methyltransferases

1986 • 17 citations

Eukaryotic DNA methyltransferase: tissue and species distribution

1988 • 6 citations