DNA Demethylation In Vitro: Involvement of RNA

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1990 • 1,270 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

DNA Repair Enzymes

1982 • 905 citations

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

1992 • 729 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

DNA methylation and gene expression

1991 • 685 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

The somatic replication of DNA methylation

1981 • 368 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

A Myogenic Cell Line with Altered Serum Requirements for Differentiation

1977 • 305 citations

DNA methylation and gene expression.

1991 • 291 citations

Methylation of CpG sequences in eukaryotic DNA

1981 • 289 citations

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

1990 • 253 citations

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis

1991 • 246 citations

Effect of regional DNA methylation on gene expression.

1985 • 232 citations

Isolation of transforming DNA: Cloning the hamster aprt gene

1980 • 226 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

A role for nuclear NF–κB in B–cell–specific demethylation of the Igκ locus

1996 • 216 citations

A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility

1995 • 212 citations

Multiple magnesium ions in the ribonuclease P reaction mechanism

1993 • 192 citations

Methylation of foreign DNA sequences in eukaryotic cells.

1980 • 190 citations

B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence

1994 • 175 citations

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.

1986 • 175 citations

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

1993 • 160 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

Demethylation of CpG islands in embryonic cells

1991 • 151 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo.

1993 • 138 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

Mechanisms of DNA Demethylation in Chicken Embryos

1995 • 129 citations

Gene methylation patterns and expression

1993 • 114 citations

Gene Activation by 5-Azacytidine

1984 • 74 citations

Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase

1993 • 69 citations

DNA Methylation in Early Mammalian Development

1984 • 65 citations

Group II intron ribozymes that cleave DNA and RNA linkages with similar efficiency, and lack contacts with substrate 2′-hydroxyl groups

1995 • 63 citations

New reactions catalyzed by a group II intron ribozyme with RNA and DNA substrates

1992 • 63 citations

Photosynthetic protein phosphorylation in intact chloroplasts

1981 • 56 citations

Delta-crystallin genes become hypomethylated in postmitotic lens cells during chicken development.

1987 • 35 citations