Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

The Rb/E2F pathway and cancer

2001 • 913 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

1999 • 731 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Myc activates telomerase

1998 • 650 citations

Drosophila myc Regulates Cellular Growth during Development

1999 • 637 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

2000 • 504 citations

New light on Myc and Myb. Part II. Myb.

1990 • 487 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Identification of CDK4 as a target of c-MYC

2000 • 457 citations

Ras Enhances Myc Protein Stability

1999 • 452 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1999 • 357 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

1999 • 330 citations

New light on Myc and Myb. Part I. Myc.

1990 • 325 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Identification of c-myc responsive genes using rat cDNA microarray.

2000 • 261 citations

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1997 • 211 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

2001 • 201 citations

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

2000 • 194 citations

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

1998 • 190 citations

E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability

2000 • 189 citations

Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins

2000 • 183 citations

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

1998 • 177 citations

Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

2000 • 173 citations

c-Myc induces the expression and activity of ornithine decarboxylase.

1993 • 152 citations

3. Teratocarcinomas and Embryonic Stem Cells

2016 • 141 citations

Complex Transcriptional Regulatory Mechanisms Control Expression of the E2F3 Locus

2000 • 139 citations

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

1996 • 127 citations

Deleted Work

1955 • 0 citations

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