Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

Handbook of clinical neurology

1986 • 1,951 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Leukemia and lymphoma in ataxia telangiectasia

1996 • 619 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

1996 • 502 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Ataxia-telangiectasia and cellular responses to DNA damage.

1995 • 378 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

1996 • 236 citations

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

1997 • 227 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.

1983 • 210 citations

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

1997 • 202 citations

Key Roles for E2F1 in Signaling p53-Dependent Apoptosis and in Cell Division within Developing Tumors

1998 • 192 citations

Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice

1997 • 169 citations

The Product of the ATM Gene Is a 370-kDa Nuclear Phosphoprotein

1996 • 131 citations

Genomic instability and the role of p53 mutations in cancer cells

1995 • 109 citations

Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm^−/− Mice

1998 • 101 citations

Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.

1994 • 99 citations

Influence of ATM function on telomere metabolism

1997 • 89 citations

Genomic instability and the role of p53 mutations in cancer cells

1995 • 87 citations

No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma

1998 • 84 citations

Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.

1997 • 83 citations

Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.

1996 • 72 citations

P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control

1997 • 57 citations

Deleted Work

1955 • 0 citations