Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Proteases to die for

1998 • 1,241 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Structure of Bax

2000 • 1,066 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

2000 • 994 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Viruses and Apoptosis

1999 • 744 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Inhibition of Fas death signals by FLIPs

1998 • 531 citations

An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs

1994 • 530 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Solution structure of the antiapoptotic protein bcl-2

2001 • 433 citations

The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

1999 • 425 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1994 • 352 citations

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.

1996 • 346 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

The polyproline region of p53 is required to activate apoptosis but not growth arrest

1997 • 318 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Cell Death Inhibition

2001 • 253 citations

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

1991 • 244 citations

Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells

1997 • 244 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

1992 • 199 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

1995 • 191 citations

Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic

1999 • 187 citations

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

1998 • 182 citations

Two Structural Transitions in Membrane Pore Formation by Pneumolysin, the Pore-Forming Toxin of Streptococcus pneumoniae

1999 • 181 citations

The structure and organization within the membrane of the helices composing the pore-forming domain of Bacillus thuringiensis δ-endotoxin are consistent with an “umbrella-like” structure of the pore

1998 • 163 citations

TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity

2000 • 141 citations

c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha.

1994 • 141 citations

The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells

1991 • 138 citations

Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

1989 • 125 citations

Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

1987 • 124 citations

Crystal Structure of Rat Bcl-xL

1997 • 121 citations

Oncogenes in tumor metabolism, tumorigenesis, and apoptosis.

1997 • 120 citations

The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody

1991 • 119 citations

bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity.

1996 • 109 citations

E1B 19K Inhibits Fas-mediated Apoptosis through FADD-dependent Sequestration of FLICE

1998 • 106 citations

Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis

1997 • 98 citations

A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells

1995 • 96 citations

Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth Arrest

1995 • 94 citations

E1B 19K Blocks Bax Oligomerization and Tumor Necrosis Factor Alpha-Mediated Apoptosis

2001 • 90 citations

p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis

1997 • 89 citations

Bcl-2 Blocks p53-Dependent Apoptosis

1994 • 87 citations

Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis

1996 • 76 citations

Regulation of Apoptosis by Adenovirus E1A and E1B Oncogenes

1998 • 76 citations

The role of human adenovirus early region 3 proteins (gp19K, 10.4K, 14.5K, and 14.7K) in a murine pneumonia model

1996 • 74 citations

Suppression of the p300-dependent mdm2negative-feedback loop induces the p53 apoptotic function

1998 • 74 citations

Insertion and Organization within Membranes of the δ-Endotoxin Pore-forming Domain, Helix 4-Loop-Helix 5, and Inhibition of Its Activity by a Mutant Helix 4 Peptide

2000 • 74 citations

Adenovirus E1A Oncogene Expression in Tumor Cells Enhances Killing by TNF-Related Apoptosis-Inducing Ligand (TRAIL)

2000 • 68 citations

The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis

1997 • 66 citations

Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis.

1997 • 58 citations

Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis

1998 • 58 citations

Analysis of Mutations in the Pore-Forming Region Essential for Insecticidal Activity of a Bacillus thuringiensis δ-Endotoxin

1999 • 56 citations

Role of tumor necrosis factor-alpha in E1A oncogene-induced susceptibility of neoplastic cells to lysis by natural killer cells and activated macrophages.

1989 • 47 citations

Inhibition of ICE-like Proteases Inhibits Apoptosis and Increases Virus Production during Adenovirus Infection

1998 • 45 citations

The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells

1991 • 43 citations

Intramembrane helix-helix interactions as the basis of inhibition of the colicin E1 ion channel by its immunity protein

1993 • 42 citations

Function of the adenovirus E1B oncogene in infected and transformed cells

1994 • 23 citations

Folded State of the Integral Membrane Colicin E1 Immunity Protein in Solvents of Mixed Polarity

2000 • 18 citations