Reorganization of Cholinergic Terminals in the Cerebral Cortex and Hippocampus in Transgenic Mice Carrying Mutated Presenilin-1 and Amyloid Precursor Protein Transgenes

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

1976 • 1,272 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Staging of Alzheimer-Related Cortical Destruction

1993 • 810 citations

Alzheimer's Disease

1986 • 772 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Evolution of the neuropathology of Alzheimer's disease

1996 • 673 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Essential role of neocortical acetylcholine in spatial memory

1995 • 310 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles

1996 • 283 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.

1996 • 245 citations

An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex

1989 • 237 citations

Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations

1992 • 225 citations

The anatomy of the CNS cholinergic neurons

1984 • 207 citations

Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage

1983 • 197 citations

Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes

1999 • 188 citations

Cholinergic depletion prevents expansion of topographic maps in somatosensory cortex.

1991 • 172 citations

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

1998 • 169 citations

Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals.

1992 • 166 citations

Mechanisms controlling neuronal plasticity in somatosensory cortex

1997 • 141 citations

An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

1998 • 131 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices.

1996 • 131 citations

Systematic regional differences in the cholinergic innervation of the primate cerebral cortex: Distribution of enzyme activities and some behavioral implications

1986 • 130 citations

Effects of muscarinic blockade in perirhinal cortex during visual recognition

1997 • 122 citations

Role of the Basal Forebrain Cholinergic Projection in Somatosensory Cortical Plasticity

1998 • 115 citations

Beta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices

1996 • 110 citations

Amyloid β-protein precursor: new clues to the genesis of Alzheimer's disease

1994 • 97 citations

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

1984 • 91 citations

Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer's disease and aging

1985 • 72 citations

Nerve Growth Factor and the Monosialoganglioside GM1: Analogous and Different in Vivo Effects on Biochemical, Morphological, and Behavioral Parameters of Adult Cortically Lesioned Rats

1994 • 63 citations

Synaptic numbers across cortical laminae and cognitive performance of the rat during ageing

1998 • 55 citations

Development and application of a monoclonal rat peroxidase antiperoxidase (PAP) immunocytochemical reagent

1984 • 45 citations

Development of a mouse antiperoxidase secreting hybridoma for use in the production of a mouse PAP complex for immunocytochemistry and as a parent cell line in the development of hybrid hybridomas

1985 • 42 citations

TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo

1998 • 11 citations