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1996 • 2,543 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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1989 • 1,752 citations

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1992 • 1,723 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

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Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

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A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

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Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

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APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

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Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

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Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

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Elevated circulating tumor necrosis factor levels in Alzheimer's disease

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Inflammation and Alzheimer's disease pathogenesis

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Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

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The importance of inflammatory mechanisms in alzheimer disease

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Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

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Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

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Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

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Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

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Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

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Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease

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Circulating cytokines in Alzheimer's disease

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Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease: A Case-Control Study in Rochester, Minnesota, 1980 Through 1984

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β-Amyloid induces increased release of interleukin-1β from lipopolysaccharide-activated human monocytes

1996 • 109 citations

Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α

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Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1991 • 105 citations

Screening for the β-amyloid precursor protein mutation (APP717: Val → Ile) in extended pedigrees with early onset Alzheimer's disease

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Galanin immunoreactivity within the primate basal forebrain: Evolutionary change between monkeys and apes

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Neurodegenerative Alzheimer-like Pathology in PDAPP 717V → F Transgenic Mice

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Evidence that transmitter‐containing dystrophic neurites precede paired helical filament and Alz‐50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease

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Early senile plaques in Alzheimer's disease demonstrated by histochemistry, immunocytochemistry, and electron microscopy

1990 • 46 citations

Glial fibrillary acidic protein and βA4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: Relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles

1990 • 42 citations

Monogenetic determinants of Alzheimer's disease: APP mutations

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Histochemical analysis of senile plaque amyloid and amyloid angiopathy

1980 • 26 citations

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