β-amyloid deposits in transgenic mice expressing human β-amyloid precursor protein have the same characteristics as those in Alzheimer's disease

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

1997 • 624 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.

1992 • 461 citations

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

1998 • 401 citations

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

1998 • 327 citations

The Profile of Soluble Amyloid β Protein in Cultured Cell Media

1996 • 293 citations

Staging of Alzheimer-Related Cortical Destruction

1997 • 209 citations

Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

1996 • 183 citations

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.

1996 • 166 citations

Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice

1997 • 151 citations

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

1996 • 109 citations

Increased plasma amyloid β protein 1–42 levels in Down syndrome

1998 • 108 citations

Apolipoprotein E4 promotes the early deposition of Aβ42 and then Aβ40 in the elderly

2000 • 80 citations

Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

2000 • 55 citations

Silver Labeling of Alzheimer Neurofibrillary Changes and Brain β-Amyloid

1993 • 51 citations

The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease

1996 • 51 citations

Kainic acid-induced activation of nuclear factor-κB in rat hippocampus

1999 • 47 citations

Pathological changes in the brain of a patient with familial Alzheimer's disease having a missense mutation at codon 717 in the amyloid precursor protein gene

1992 • 47 citations

Biochemistry of Alzheimer's disease amyloid plaques

1993 • 37 citations

Comparison of silver stainings and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections

1993 • 30 citations

Immunohistochemical localization of GABAA receptors in comparison with GABA-immunoreactive structures in the nucleus tractus solitarii of the rat

1997 • 25 citations

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

1992 • 21 citations

530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells

1996 • 18 citations