Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

NK CELL RECOGNITION

2004 • 2,685 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Roles of the NKG2D immunoreceptor and its ligands

2003 • 1,297 citations

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

1998 • 759 citations

Natural Killer Cell Signaling Pathways

2004 • 693 citations

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

1998 • 500 citations

X-Linked Lymphoproliferative Disease

2000 • 470 citations

2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48

1998 • 405 citations

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease

2003 • 325 citations

SAP couples Fyn to SLAM immune receptors

2003 • 282 citations

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

2003 • 274 citations

Cutting Edge: Functional Requirement for SAP in 2B4-Mediated Activation of Human Natural Killer Cells as Revealed by the X-Linked Lymphoproliferative Syndrome

2000 • 263 citations

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

2001 • 258 citations

High Expression of Inhibitory Receptor SHPS-1 and Its Association with Protein-tyrosine Phosphatase SHP-1 in Macrophages

1998 • 233 citations

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes.

1993 • 226 citations

Molecular and cellular pathogenesis of X‐linked lymphoproliferative disease

2005 • 215 citations

Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells.

1993 • 206 citations

2B4 Acts As a Non–Major Histocompatibility Complex Binding Inhibitory Receptor on Mouse Natural Killer Cells

2004 • 201 citations

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)

2005 • 198 citations

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoingin vitrodifferentiation

2002 • 187 citations

A new self: MHC-class-I-independent Natural-killer-cell self-tolerance

2005 • 175 citations

Identification of the 2B4 molecule as a counter-receptor for CD48.

1998 • 169 citations

Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity

2000 • 169 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells

2001 • 150 citations

Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease

2000 • 150 citations

Genetic Evidence Linking SAP, the X-Linked Lymphoproliferative Gene Product, to Src-Related Kinase FynT in TH2 Cytokine Regulation

2004 • 146 citations

Cutting Edge: Identification of the 2B4 Molecule as a Counter-Receptor for CD48

1998 • 140 citations

Mouse Ly-49D Recognizes H-2Dd and Activates Natural Killer Cell Cytotoxicity

1999 • 137 citations

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

2002 • 125 citations

Molecular Dissection of 2B4 Signaling: Implications for Signal Transduction by SLAM-Related Receptors

2004 • 122 citations

PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates

2001 • 120 citations

The SLAM family of immune-cell receptors

2003 • 119 citations

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn

2005 • 119 citations

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene.

1996 • 109 citations

Targeted Disruption of the2B4Gene in Mice Reveals an In Vivo Role of 2B4 (CD244) in the Rejection of B16 Melanoma Cells

2005 • 92 citations

A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells

2005 • 79 citations

The SAP family of adaptors in immune regulation

2004 • 54 citations

SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors

2004 • 31 citations