Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Mice lacking MHC class II molecules

1991 • 869 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

1995 • 384 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Article

1995 • 325 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Editing of the HLA-DR-peptide repertoire by HLA-DM.

1996 • 273 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex

1988 • 205 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

Cell biology of antigen presentation

1993 • 166 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.

1996 • 146 citations

Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated alpha beta dimers.

1993 • 145 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments

1996 • 122 citations

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.

1996 • 121 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

1997 • 108 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.

1996 • 102 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

Antigen presentation of hen egg‐white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II‐associated invariant chain

1991 • 74 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways.

1993 • 65 citations

Cell surface expression of class II MHC proteins bound by a single peptide.

1995 • 63 citations

Epitope-specific enhancement of antigen presentation by invariant chain.

1993 • 52 citations

The influence of invariant chain on the positive selection of single T cell receptor specificities

1995 • 49 citations

Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptide.

1988 • 44 citations

Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain.

1995 • 42 citations

Implications of the invariant gamma-chain on the intracellular transport of class II histocompatibility antigens.

1985 • 38 citations

Invariant chain influences post-translational processing of HLA-DR molecules.

1991 • 35 citations

Structure-function relationship among T-cell receptors specific for lysozyme peptides bound to Ab or Abm-12 molecules.

1992 • 18 citations

Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II molecules.

1995 • 11 citations