Cyclic nucleotide phosphodiesterase (PDE) inhibitors and immunomodulation

Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure

1991 • 2,186 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 2,097 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

Modulation of Inflammation and Immunity by Cyclic AMP

1974 • 923 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 759 citations

Phosphodiesterase Isozymes

1998 • 655 citations

Oral Sildenafil in the Treatment of Erectile Dysfunction

1998 • 627 citations

Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity.

1970 • 462 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

Tailoring cAMP-signalling responses through isoform multiplicity

1997 • 437 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

“The Role of Cyclic 3′, 5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes”

1972 • 388 citations

The Role of Cyclic 3′,5′ Adenosine Monophosphate in the Specific Cytolytic Activity of Lymphocytes

1972 • 305 citations

Hydrolysis of Cyclic Guanosine and Adenosine 3',5'-Monophosphates by Rat and Bovine Tissues

1970 • 303 citations

Effects of Theophylline on Diaphragmatic Strength and Fatigue in Patients with Chronic Obstructive Pulmonary Disease

1984 • 290 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs.

1986 • 230 citations

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4⁺ and CD8⁺ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

1996 • 218 citations

Type 4 Phosphodiesterase Inhibitors Have Clinical and In Vitro Anti-inflammatory Effects in Atopic Dermatitis

1996 • 217 citations

THE PROPERTIES OF AN ADENINE RIBONUCLEOTIDE PRODUCED WITH CELLULAR PARTICLES, ATP, Mg⁺⁺, AND EPINEPHRINE OR GLUCAGON

1957 • 204 citations

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1997 • 186 citations

Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production

1998 • 185 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst1

1990 • 176 citations

National Asthma Education Program

1990 • 176 citations

Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate.

1988 • 164 citations

Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

1996 • 161 citations

The genetic subtypes of cAMP-dependent protein kinase — Functionally different or redundant?

1993 • 160 citations

Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.

1995 • 152 citations

Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.

1992 • 139 citations

Characterization of cAMP-dependent inhibition of LPS-induced TNFα production by rolipram, a specific phosphodiesterase IV (PDE IV) inhibitor

1994 • 136 citations

SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions.

1998 • 135 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Differential regulation of human monocyte-derived TNF alpha and IL-1 beta by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors.

1995 • 135 citations

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

The Role of Cyclic AMP in the Cytolytic Activity of Lymphocytes

1971 • 130 citations

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

1995 • 129 citations

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

1993 • 127 citations

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

1992 • 124 citations

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

1997 • 121 citations

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.

1995 • 118 citations

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant

1997 • 115 citations

Effects of theophylline and rolipram on leukotriene C₄ (LTC₄) synthesis and chemotaxis of human eosinophils from normal and atopic subjects

1996 • 106 citations

Phosphodiesterase Inhibition by Ro 20-1724 Reduces Hyper-IgE Synthesis by Atopic Dermatitis Cells In Vitro

1985 • 104 citations

Differential effects of non‐selective and selective phosphodiesterase inhibitors on human eosinophil functions

1995 • 102 citations

Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

1994 • 101 citations

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

1996 • 99 citations

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

1994 • 96 citations

Differential inhibition of human neutrophil functions

1990 • 95 citations

Salbutamol Up-regulates PDE4 Activity and Induces a Heterologous Desensitization of U937 Cells to Prostaglandin E2

1995 • 92 citations

Characterization of an Intronic Promoter of a Cyclic Adenosine 3′,5′-Monophosphate (cAMP)-Specific Phosphodiesterase Gene that Confers Hormone and cAMP Inducibility

1997 • 90 citations

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

1994 • 88 citations

Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function

1997 • 88 citations

Suppression of human eosinophil respiratory burst and cyclic AMP hydrolysis by inhibitors of type IV phosphodiesterase: interaction with the beta adrenoceptor agonist albuterol.

1994 • 86 citations

Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response

1993 • 86 citations

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B.

1996 • 85 citations

Increased Interleukin-4 Production by Atopic Mononuclear Leukocytes Correlates with Increased Cyclic Adenosine Monophosphate – Phosphodiesterase Activity and Is Reversible by Phosphodiesterase Inhibition

1993 • 85 citations

Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

1995 • 85 citations

Preliminary identification and role of phosphodiesterase isozymes in human basophils.

1992 • 83 citations

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1994 • 82 citations

Alternative Splicing of cAMP-specific Phosphodiesterase mRNA Transcripts

1996 • 82 citations

Theophylline: Recent Advances in the Understanding of Its Mode of Action and Uses in Clinical Practice

1998 • 81 citations

Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids

1995 • 80 citations

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram

1996 • 80 citations

Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma

1992 • 80 citations

Cyclic nucleotide phosphodiesterases from purified human CD4⁺ and CD8⁺ T lymphocytes

1995 • 79 citations

Therapeutic potential of phosphodiesterase type 4 inhibition in chronic autoimmune demyelinating disease

1997 • 77 citations

Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics

1996 • 77 citations

Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV.

1996 • 75 citations

On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter.

1985 • 74 citations

Effects of cAMP-Phosphodiesterase Isozyme Inhibitor on Cytokine Production by Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells

1997 • 74 citations

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1995 • 72 citations

Phosphodiesterase profiles of highly purified human peripheral blood leukocyte populations from normal and atopic individuals: A comparative study☆☆☆★★★

1997 • 72 citations

Reduction in Pulmonary Hypertension and in Airway Resistances by Enoximone (MDL 17,043) in Decompensated COPD

1987 • 71 citations

Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.

1993 • 70 citations

Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study

1996 • 69 citations

Phosphodiesterase II, the cGMP-activatable cyclic nucleotide phosphodiesterase, regulates cyclic AMP metabolism in PC12 cells.

1991 • 65 citations

Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram

1997 • 64 citations

Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors.

1997 • 63 citations

Determination of the Structure of the N-terminal Splice Region of the Cyclic AMP-specific Phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and Identification of the Membrane Association Domain Using Chimeric Constructs

1996 • 63 citations

Zinc Dependent Activation of cAMP-Specific Phosphodiesterase (PDE4A)

1997 • 62 citations

The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages

1993 • 61 citations

Cyclic Nucleotide Phosphodiesterases: Gene Complexity, Regulation by Phosphorylation, and Physiological Implications

1996 • 59 citations

Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines

1981 • 55 citations

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase

1996 • 53 citations

Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein.

1997 • 52 citations

Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils

1995 • 52 citations

The National Asthma Education Program. Expert panel report guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute.

1993 • 52 citations

Recombinant Expression of a Type IV, cAMP-Specific Phosphodiesterase: Characterization and Structure−Function Studies of Deletion Mutants

1997 • 50 citations

Characterization of an Intronic Promoter of a Cyclic Adenosine 3',5'-Monophosphate (cAMP)-Specific Phosphodiesterase Gene that Confers Hormone and cAMP Inducibility

1997 • 50 citations

Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors

1986 • 50 citations

Cyclic nucleotide phosphodiesterases in the human lung

1994 • 50 citations

Differential efficacy of lymphocyte- and monocyte-selective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression

1997 • 49 citations

Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M & B 22,948)

1983 • 48 citations

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse

1994 • 48 citations

Trials of the bronchodilator activity of the isoenzyme‐selective phosphodiesterase inhibitor AH 21‐132 in healthy volunteers during a methacholine challenge test.

1992 • 47 citations

Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

1997 • 45 citations

Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

1997 • 43 citations

Tumour necrosis factor alpha‐induced oxidative burst in neutrophils adherent to fibronectin: effects of cyclic AMP‐elevating agents

1995 • 42 citations

Bronchodilator and bronchoprotective effects of cilostazol in humans in vivo.

1995 • 41 citations

Identification of cyclic AMP‐phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

1996 • 40 citations

Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo.

1993 • 40 citations

Effects of inhibitors of phosphodiesterase, on antigen‐induced bronchial hyperreactivity in conscious sensitized guinea‐pigs and airway leukocyte infiltration

1997 • 39 citations

Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

1997 • 38 citations

Regulation of interleukin-13 by type 4 cyclic nucleotide phosphodiesterase (PDE) inhibitors in allergen-specific human T lymphocyte clones

1997 • 35 citations

The specific type IV phosphodiesterase inhibitor rolipram differentially regulates the proinflammatory mediators TNF-α and nitric oxide

1995 • 33 citations

Suppression of tumor necrosis factor-α production by interleukin-10 is enhanced by cAMP-elevating agents

1997 • 33 citations

Inhibition of Antigen-induced Pulmonary Eosinophilia and Neutrophilia by Selective Inhibitors of Phosphodiesterase Types 3 or 4 in Brown Norway Rats

1995 • 33 citations

Cyclic AMP phosphodiesterases in human lymphocytes

1997 • 32 citations

Theophylline and Mucociliary Clearance

1987 • 30 citations

Rolipram, a Phosphodiesterase-4-Selective Inhibitor, Promotes the Survival of Cultured Rat Dopaminergic Neurons.

1997 • 29 citations

cAMP-specific phosphodiesterase inhibitor, rolipram, reduces eosinophil infiltration evoked by leukotrienes or by histamine in guinea pig conjunctiva

1993 • 25 citations

Cardiovascular cyclic nucleotide phosphodiesterases and their role in regulating cardiovascular function

1992 • 25 citations

Effect of a Phosphodiesterase 3 Inhibitor, Cilostazol, on Bronchial Hyperresponsiveness in Elderly Patients with Asthma

1997 • 24 citations

Role of Cyclic Nucleotides and Nitric Oxide in Blood Mononuclear Cell IgE Production Stimulated by IL-4

1995 • 21 citations

Interactions of formylmethionyl‐leucyl‐phenylalanine, adenosine, and phosphodiesterase inhibitors in human monocytes Effects on superoxide release, inositol phosphates and cAMP

1989 • 21 citations

Theophylline Does not Increase Ventilatory Responses to Hypercapnia or Hypoxia

1992 • 18 citations

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: ‘designer’ changes in Vmax, stability and membrane association

1995 • 14 citations

Effect of Cyclic AMP-Elevating Agents on Human Spontaneous IgE Synthesis in vitro

1984 • 13 citations

The effect of zaprinast (M&B 22,948, an orally absorbed mast cell stabilizer) on exercise-induced asthma in children

1986 • 13 citations

Pharmacologic Control of Histamine Release from Human Basophils Induced by Platelet-Activating Factor

1993 • 12 citations

Antagonists of cyclic nucleotide phosphodiesterase (PDE) isozymes PDE 3 and PDE 4 suppress lymphoblastic response to HLA class II alloantigens: a potential novel approach to preventing allograft rejection?

1997 • 11 citations

Interactions between cAMP- and cGMP-dependent protein kinase inhibitors and phosphodiesterase IV inhibitors on arachidonate release from human monocytes

1996 • 9 citations

Rolipram, a Phosphodiesterase-4-Selective Inhibitor, Promotes the Survival of Cultured Rat Dopaminergic Neurons

1997 • 8 citations

Pulmonary antiallergic and antiinflammatory effects of a novel, orallyactive phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats

1995 • 7 citations

Regulation of Cyclic AMP Phosphodiesterase Activity by Particulate Protein Tyrosine Kinase and Phosphotyrosine Phosphatase Activities Sensitive to Sodium Orthovanadate.

1995 • 7 citations

EFFECT OF XANTHINE DERIVATIVES ON CHEMOTACTIC POLYPEPTIDE-INDUCED SUPEROXIDE AND ENZYME RELEASE FROM HUMAN POLYMORPHONUCLEAR LEUCOCYTES

1993 • 1 citations