Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis

Baculovirus expression vectors: a laboratory manual.

1992 • 1,799 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases

1995 • 313 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function

1991 • 250 citations

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993 • 233 citations

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

1989 • 171 citations

Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: A diverse family of regulatory enzymes

1994 • 135 citations

Inhibitors of Cyclic Nucleotide Phosphodiesterase Isoenzymes—their Potential Utility in the Therapy of Asthma

1994 • 134 citations

Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

1990 • 133 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA.

1993 • 130 citations

PDE isoenzymes as targets for anti-asthma drugs

1995 • 129 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Cyclic nucleotide phosphodiesterases : structure, regulation and drug action

1990 • 112 citations

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

1994 • 108 citations

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

1994 • 92 citations

Alternative Splicing of cAMP-specific Phosphodiesterase mRNA Transcripts

1996 • 82 citations

The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family

1993 • 75 citations

Molecular cloning and functional expression in yeast of a human cAMP‐specific phosphodiesterase subtype (PDE IV‐C)

1995 • 74 citations

A separation method for the assay of adenylylcyclase, intracellular cyclic AMP, and cyclic-AMP phosphodiesterase using tritium-labeled substrates

1992 • 67 citations

Characterization of a hormone-inducible, high affinity adenosine 3',5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell

1995 • 57 citations

Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.

1993 • 56 citations

Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD)

1994 • 46 citations

Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium.

1995 • 46 citations

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

1994 • 45 citations

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19

1995 • 42 citations

Unique Adenosine 3′,5′ Cyclic Monophosphate Phosphodiesterase Messenger Ribonucleic Acids in Rat Spermatogenic Cells: Evidence for Differential Gene Expression during Spermatogenesis1

1992 • 34 citations

Molecular Cloning and Expression of a Human Phosphodiesterase 4C

1997 • 30 citations

Stage and cell-specific expression of the adenosine 3',5' monophosphate- phosphodiesterase genes in the rat seminiferous epithelium

1995 • 16 citations

Characterization of two human cAMP‐specific phosphodiesterase subtypes expressed in baculovirus‐infected insect cells.

1995 • 11 citations

An Isoform-selective Inhibitor of Cyclic AMP-Specific Phosphodiesterase (PDE4) with Anti-inflammatory Properties

1996 • 10 citations

Cyclic Nucleotide Phosphodiesterase Superfamily

2006 • 9 citations