Suppression of tumor necrosis factor-α production by interleukin-10 is enhanced by cAMP-elevating agents

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin-10

1993 • 1,820 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

Interleukin 10 protects mice from lethal endotoxemia.

1993 • 807 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

1992 • 525 citations

A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

1995 • 415 citations

Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.

1986 • 396 citations

IL-10: a novel cytotoxic T cell differentiation factor.

1991 • 391 citations

Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease

1995 • 368 citations

Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

1992 • 352 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Identification and induction of keratinocyte-derived IL-10.

1992 • 342 citations

Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs

1995 • 318 citations

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.

1991 • 248 citations

Effect of tumor necrosis factor alpha on mitogen-activated human B cells.

1987 • 245 citations

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

1983 • 239 citations

Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells.

1991 • 235 citations

The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells

1993 • 222 citations

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha.

1988 • 221 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Measurement of immunoreactive interleukin-1β from human mononuclear cells: Optimization of recovery, intrasubject consistency, and comparison with interleukin-1α and tumor necrosis factor

1988 • 173 citations

Concentrations of Immunoreactive Human Tumor Necrosis Factor Alpha Produced by Human Mononuclear Cells In Vitro

1988 • 172 citations

Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.

1995 • 159 citations

Xanthine derivatives: comparison between suppression of tumour necrosis factor-alpha production and inhibition of cAMP phosphodiesterase activity.

1993 • 140 citations

Prostacyclin analogs suppress the synthesis of tumor necrosis factor-α in LPS-stimulated human peripheral blood mononuclear cells

1993 • 102 citations

Endogenous Adenosine Curtails Lipopolysaccharide‐Stimulated Tumour Necrosis Factor Synthesis

1997 • 92 citations

Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas

1990 • 88 citations

Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids

1995 • 80 citations

Disruption of microtubule network in human monocytes induces expression of interleukin-1 but not that of interleukin-6 nor tumor necrosis factor-alpha. Involvement of protein kinase A stimulation

1993 • 59 citations

Therapeutic intervention in a rat model of ARDS: IV. Phosphodiesterase IV inhibition.

1993 • 51 citations

The cooperative effects of TNF-α and IFN-γ are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia

1994 • 48 citations

The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice.

1989 • 24 citations

Cicaprost and the type IV phosphodiesterase inhibitor, rolipram, synergize in suppression of tumor necrosis factor-α synthesis

1996 • 17 citations