Origins of CD4+ effector and central memory T cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Differentiation of Effector CD4 T Cell Populations

2010 • 3,135 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

2009 • 1,494 citations

mTOR regulates memory CD8 T-cell differentiation

2009 • 1,473 citations

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

2009 • 1,425 citations

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

2011 • 1,406 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

2008 • 1,138 citations

Fate mapping of IL-17-producing T cells in inflammatory responses

2011 • 1,086 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Late Developmental Plasticity in the T Helper 17 Lineage

2009 • 1,022 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Similarities and differences in CD4+ and CD8+ effector and memory T cell generation

2003 • 865 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

2003 • 734 citations

T Follicular Helper (T_FH) Cells in Normal and Dysregulated Immune Responses

2008 • 611 citations

Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

2001 • 600 citations

Follicular Helper T Cells: Lineage and Location

2009 • 578 citations

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

2009 • 563 citations

Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

2009 • 545 citations

In Vivo Activation of Antigen-Specific CD4 T Cells

2001 • 498 citations

Analysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter

2001 • 460 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

2007 • 415 citations

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

2006 • 375 citations

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

2009 • 361 citations

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

2010 • 358 citations

CD27 Promotes Survival of Activated T Cells and Complements CD28 in Generation and Establishment of the Effector T Cell Pool

2003 • 355 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

Follicular B helper T cell activity is confined to CXCR5^hiICOS^hi CD4 T cells and is independent of CD57 expression

2006 • 318 citations

Homeostasis of memory T cells

2006 • 275 citations

Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells

2009 • 274 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

Memory CD4 T cells emerge from effector T-cell progenitors

2008 • 248 citations

T CELL RECEPTOR GENE DIVERSITY AND SELECTION

1990 • 234 citations

Antiviral CD4+ memory T cells are IL-15 dependent

2007 • 229 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

2009 • 169 citations

Requirement of B Cells for Generating CD4+ T Cell Memory

2009 • 160 citations

Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells

2008 • 153 citations

CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

2006 • 151 citations

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

1990 • 141 citations

Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors

2008 • 139 citations

In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells

2001 • 113 citations

Effector Memory Th1 CD4 T Cells Are Maintained in a Mouse Model of Chronic Malaria

2010 • 98 citations

Rapid Expansion and IL-4 Expression by Leishmania-Specific Naive Helper T Cells In Vivo

2002 • 92 citations

Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells

2007 • 88 citations

Selective Priming and Expansion of Antigen-Specific Foxp3−CD4+ T Cells during Listeria monocytogenes Infection

2009 • 70 citations

Persistence and Function of Central and Effector Memory CD4+ T Cells following Infection with a Gastrointestinal Helminth

2006 • 68 citations

IL-7 Receptor Expression Provides the Potential for Long-Term Survival of Both CD62Lhigh Central Memory T Cells and Th1 Effector Cells during Leishmania major Infection

2009 • 66 citations

Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles

2009 • 65 citations

Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection

2006 • 63 citations

Reduced Functional Avidity Promotes Central and Effector Memory CD4 T Cell Responses to Tumor-Associated Antigens

2010 • 57 citations

Heterogeneity among Viral Antigen-Specific CD4+ T Cells and Their De Novo Recruitment during Persistent Polyomavirus Infection

2010 • 20 citations

Th1 Cytokine Responses Fail to Effectively Control Chlamydia Lung Infection in ICOS Ligand Knockout Mice

2010 • 18 citations