Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Germinal Centers

1994 • 1,680 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

2009 • 1,494 citations

Bcl6 Mediates the Development of T Follicular Helper Cells

2009 • 1,403 citations

Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 • 1,379 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

2009 • 1,143 citations

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

2008 • 1,138 citations

Germinal-Center Organization and Cellular Dynamics

2007 • 928 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

Cytokine-secreting follicular T cells shape the antibody repertoire

2009 • 770 citations

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

2010 • 725 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

2010 • 709 citations

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

2004 • 703 citations

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

2008 • 702 citations

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

2008 • 689 citations

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

2009 • 641 citations

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

2005 • 641 citations

Extrafollicular antibody responses

2003 • 617 citations

ATlr7translocation accelerates systemic autoimmunity in murine lupus

2006 • 611 citations

T Follicular Helper (T_FH) Cells in Normal and Dysregulated Immune Responses

2008 • 611 citations

Subspecialization of Cxcr5+ T Cells

2001 • 590 citations

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

2008 • 584 citations

Follicular Helper T Cells: Lineage and Location

2009 • 578 citations

Follicular helper T cells are required for systemic autoimmunity

2009 • 570 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells

2007 • 485 citations

Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood

2008 • 411 citations

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells

2009 • 405 citations

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

2008 • 386 citations

ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells

2006 • 375 citations

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

2009 • 370 citations

IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

2009 • 356 citations

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

2008 • 349 citations

Early commitment of naïve human CD4⁺ T cells to the T follicular helper (T_FH) cell lineage is induced by IL‐12

2009 • 326 citations

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

2009 • 326 citations

Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

2010 • 322 citations

Follicular B helper T cell activity is confined to CXCR5^hiICOS^hi CD4 T cells and is independent of CD57 expression

2006 • 318 citations

Cutting Edge: IL-21 Is a Switch Factor for the Production of IgG1 and IgG3 by Human B Cells

2004 • 304 citations

Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells

2004 • 289 citations

Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis

2007 • 284 citations

Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-21

2006 • 265 citations

In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development

2010 • 264 citations

Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

1994 • 260 citations

Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus

2001 • 254 citations

Unique gene expression program of human germinal center T helper cells

2004 • 246 citations

Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells

2008 • 218 citations

Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells

1994 • 214 citations

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

2008 • 213 citations

Live-cell assay to detect antigen-specific CD4+ T-cell responses by CD154 expression

2006 • 201 citations

Cutting Edge: Induction of Follicular Homing Precedes Effector Th Cell Development

2001 • 103 citations

Mechanisms of Disease: autoantigens as clues to the pathogenesis of myositis

2008 • 99 citations

CXCR3 Is Induced Early on the Pathway of CD4+ T Cell Differentiation and Bridges Central and Peripheral Functions

2003 • 90 citations

Repression of BCL-6 is required for the formation of human memory B cells in vitro

2007 • 80 citations

Two sides of a cellular coin: CD4+CD3− cells regulate memory responses and lymph-node organization

2005 • 76 citations

Pediatric psoriasis and psoriatic arthritis

2004 • 65 citations