Modulation of Tumor Necrosis Factor and Interleukin-1-dependent NF-κB Activity by mPLK/IRAK

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 • 1,198 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements

1985 • 698 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants

1998 • 573 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1997 • 449 citations

The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response

1995 • 386 citations

The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)

1997 • 311 citations

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

1997 • 281 citations

Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38

1998 • 267 citations

Association of the p75 Neurotrophin Receptor with TRAF6

1999 • 237 citations

Phosphatidylinositol 3-Kinase in Interleukin 1 Signaling

1997 • 231 citations

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein

1997 • 227 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

1998 • 195 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

1994 • 187 citations

Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus.

1993 • 171 citations

Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2

1997 • 117 citations

Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element.

1997 • 64 citations

Tumor Necrosis Factor Receptors (Tnfr) in Mouse Fibroblasts Deficient in Tnfr1 or Tnfr2 are Signaling Competent and Activate the Mitogen-activated Protein Kinase Pathway with Differential Kinetics

1996 • 62 citations

The IL1 receptor accessory protein is responsible for the recruitment of the interleukin‐1 receptor associated kinase to the IL1/IL1 receptor I complex

1997 • 55 citations

Regulation of interleukin (IL)-11 gene expression in IL-1 induced primate bone marrow stromal cells

1994 • 48 citations

Developmental and Tissue-specific Expression of Mouse Pelle-like Protein Kinase

1996 • 35 citations

Mutational analysis of Cak1p, an essential protein kinase that regulates cell cycle progression

1997 • 26 citations