The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation

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1995 • 2,534 citations

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1995 • 2,199 citations

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1994 • 2,124 citations

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1994 • 2,110 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

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1996 • 1,361 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

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1995 • 1,266 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 • 1,154 citations

Two TNF receptors

1992 • 1,048 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

1995 • 964 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

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1995 • 800 citations

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1995 • 780 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis.

1996 • 540 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

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1996 • 379 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

1991 • 324 citations

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1994 • 320 citations

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1992 • 248 citations

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1995 • 234 citations

Role of I Bα Ubiquitination in Signal-induced Activation of NF- B in Vivo

1996 • 216 citations

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

1993 • 211 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

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1992 • 199 citations

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1996 • 193 citations

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1987 • 189 citations

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1995 • 183 citations

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1992 • 180 citations

NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity

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1996 • 155 citations

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1987 • 132 citations

A Gradient of Cactus Protein Degradation Establishes Dorsoventral Polarity in theDrosophilaEmbryo

1996 • 124 citations

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

1994 • 120 citations

Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells.

1993 • 111 citations

Affinity purification and chemical analysis of the interleukin-1 receptor.

1988 • 86 citations

Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis

1995 • 77 citations

Interleukin‐1‐induced activation of a protein kinase co‐precipitating with the type I interleukin‐1 receptor in T cells

1994 • 76 citations

Biology of the Interleukin-1 Receptor

1990 • 53 citations

Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor.

1994 • 52 citations

Appearance of apparently ubiquitin-conjugated lκB-α during its phosphorylation-induced degradation in intact cells

1995 • 51 citations

TNF receptor signal transduction. Ligand-dependent stimulation of a serine protein kinase activity associated with (CD120a) TNFR60.

1994 • 48 citations

Developmental and Tissue-specific Expression of Mouse Pelle-like Protein Kinase

1996 • 35 citations

Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors.

1996 • 34 citations

Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.

1994 • 28 citations