Aurora-A Kinase Interacting Protein (AIP), a Novel Negative Regulator of Human Aurora-A Kinase

Genomic sequencing.

1984 • 8,343 citations

Principles of CDK regulation

1995 • 3,267 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

2001 • 562 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Polo-like kinases: a team that plays throughout mitosis

1998 • 424 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Regulation of the APC and the exit from mitosis

1999 • 375 citations

Polo-like kinases: positive regulators of cell division from start to finish

1998 • 346 citations

pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

1998 • 341 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

1999 • 289 citations

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

1994 • 271 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.

1997 • 199 citations

Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes.

1994 • 187 citations

Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes

1999 • 158 citations

Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

1999 • 149 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

1997 • 138 citations

Regulation of APC Activity by Phosphorylation and Regulatory Factors

1999 • 136 citations

The mitotic roles of Polo-like kinase

2001 • 123 citations

The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner

2001 • 118 citations

Distribution of cytoskeletal proteins sharing a conserved phosphorylated epitope.

1986 • 118 citations

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope

1990 • 108 citations

Regulation of Chromosome Segregation by Glc8P, a Structural Homolog of Mammalian Inhibitor 2 That Functions as both an Activator and an Inhibitor of Yeast Protein Phosphatase 1

1995 • 97 citations

Dynamic Changes in Nuclear Architecture during Mitosis: On the Role of Protein Phosphorylation in Spindle Assembly and Chromosome Segregation

1996 • 94 citations

Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly

1989 • 92 citations

cDNA Cloning, Expression, Subcellular Localization, and Chromosomal Assignment of Mammalian Aurora Homologues, Aurora-Related Kinase (ARK) 1 and 2

1998 • 81 citations

Balanced regulation of microtubule dynamics during the cell cycle: a contemporary view

1999 • 73 citations

DNA amplifications at 20q13 and MDM2 define distinct subsets of evolved breast and ovarian tumours

1996 • 72 citations

Cdc20 associates with the kinase aurora2/Aik

1999 • 68 citations

MDM2 Can Promote the Ubiquitination, Nuclear Export, and Degradation of p53 in the Absence of Direct Binding

2001 • 53 citations

Cell cycle: Checkpoint proteins and kinetochores

1997 • 44 citations

Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase

1996 • 33 citations

Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma

2001 • 24 citations