Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

RIBBONS 2.0

1991 • 814 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

1999 • 533 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Structure of GSK3beta reveals a primed phosphorylation mechanism.

2001 • 368 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

2000 • 301 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Association of centrosomal kinaseSTK15/BTAK mRNA expression with chromosomal instability in human breast cancers

2001 • 231 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

1998 • 136 citations

Activity of the MAP kinase ERK2 is controlled by a flexible surface loop

1995 • 123 citations

ATP site-directed competitive and irreversible inhibitors of protein kinases

2000 • 117 citations

Crystal Structure of a Polyhistidine-Tagged Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with the Peptide Inhibitor PKI(5−24) and Adenosine

1997 • 112 citations

Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.

2001 • 98 citations

Dynamic Changes in Nuclear Architecture during Mitosis: On the Role of Protein Phosphorylation in Spindle Assembly and Chromosome Segregation

1996 • 94 citations

Recent developments for the efficient crystallographic refinement of macromolecular structures

1998 • 81 citations

The centrosome-associated aurora/Ipl-like kinase family

1999 • 65 citations

Domain Interactions in Protein Tyrosine Kinase Csk

1999 • 63 citations

Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1-13.2

1998 • 58 citations

Loss of Heterozygosity in Human Ovarian Cancer on Chromosome 19q

1997 • 48 citations

Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement

1991 • 39 citations