Round Window Membrane Delivery of l-Methionine Provides Protection from Cisplatin Ototoxicity Without Compromising Chemotherapeutic Efficacy

Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer.

1996 • 455 citations

Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA

1985 • 436 citations

Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants

1996 • 284 citations

Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells.

1997 • 262 citations

NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells

1996 • 251 citations

d-Methionine provides excellent protection from cisplatin ototoxicity in the rat

1996 • 235 citations

Mechanism of Protection by Diethyldithiocarbamate against Cisplatin Ototoxicity: Antioxidant System

1995 • 164 citations

Cisplatin Nephrotoxicity

1986 • 164 citations

Ototoxicity of the Anticancer Drug Cisplatin:An Experimental Study

1982 • 163 citations

Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro

1995 • 163 citations

Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein.

1998 • 163 citations

Ototoxicity of Chemotherapeutic Agents

1993 • 153 citations

Experimental studies on round window structure: Function and permeability

1988 • 151 citations

High‐Dose cisplatin treatment: Hearing loss and plasma concentrations

1990 • 150 citations

Osmotic pump implant for chronic infusion of drugs into the inner ear

1993 • 145 citations

D-Methionine protects against cisplatin damage to the stria vascularis

1999 • 119 citations

Review of Round Window Membrane Permeability

1988 • 111 citations

Protection of Both Auditory Hair Cells and Auditory Neurons from Cisplatin Induced Damage

1997 • 99 citations

First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate.

1998 • 94 citations

Risk Factors for Ototoxicity due to Cisplatin

1994 • 83 citations

Effects of cisplatin and thiosulfate upon auditory brainstem responses of guinea pigs

1988 • 82 citations

Dose-dependent inner ear changes after i.v. administration of cisplatin.

1991 • 81 citations

Ototoxicity Due to Cis-diamminedichloro-platinum in the Treatment of Ovarian Cancer

1991 • 76 citations

Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester

1995 • 75 citations

Cisplatin and platinum analogues

1992 • 70 citations

L- and D- methionine provide equivalent long term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity.

1999 • 68 citations

Effect of 4-methylthiobenzoic acid on cisplatin-induced ototoxicity in the rat

1999 • 57 citations

l-Methionine antagonism of cis-platinum nephrotoxicity

1990 • 47 citations

The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons

1999 • 42 citations

Some procedures to reduce cis-platinum toxicity reduce antitumour activity

1987 • 41 citations

Thiol and thioether suppression of cis-platinum-induced nephrotoxicity in rats bearing the Walker 256 carcinosarcoma.

1989 • 38 citations

The nephrotoxicity, cytotoxicity and renal handling of a cisplatin-methionine complex in male Wistar rats

1994 • 36 citations

Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of γ-glutamyl-cycle enzymes

1986 • 33 citations

Evaluation of cisplatin dose intensity: current status and future prospects.

1989 • 33 citations

The round window membrane under normal and pathological conditions.

1992 • 33 citations

Pharmacological interventions to reduce platinum-induced toxicity

1990 • 28 citations

Dithiocarbamate-induced biliary platinum excretion and the control of cis-platinum nephrotoxicity

1989 • 25 citations

Oral chemotherapy for poor risk small-cell lung cancer patients with combined idarubicin and etoposide

1990 • 9 citations

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