The discovery of thrombomodulin

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

1979 • 480 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

1979 • 356 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Proteolytic activation of protein C from bovine plasma

1976 • 211 citations

Clearance of Thrombin from Circulation in Rabbits by High-affinity Binding Sites on Endothelium

1980 • 204 citations

Binding of human thrombin to cultured human endothelial cells.

1979 • 193 citations

Protein C Inhibitor Is a Potent Inhibitor of the Thrombin-Thrombomodulin Complex

1995 • 174 citations

A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase.

1976 • 134 citations

New Therapeutic Agents in Thrombosis and Thrombolysis

2011 • 120 citations

Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan.

1990 • 99 citations

Use of endothelium cultured on microcarriers as a model for the microcirculation.

1982 • 98 citations

Binding of thrombin to cultured human endothelial cells. Nonequilibrium aspects.

1980 • 72 citations

Platelet factor 4 enhances generation of activated protein C in vitro and in vivo

2003 • 66 citations

Perspectives in Inflammation, Neoplasia, and Vascular Cell Biology

1988 • 8 citations

INTERACTION OF THROMBIN WITH THE VASCULAR ENDOTHELIUM IN A RECIRCULATING LANGENDORFF RABBIT HEART PREPARATION*

1982 • 7 citations

VIII. Protein C and Autoprothrombin II-A

1981 • 6 citations

Modulation of the Protein C Pathway as a Therapy for Thrombosis

2002 • 2 citations