High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993

1999 • 1,967 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

2004 • 1,533 citations

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

2003 • 1,200 citations

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

2000 • 1,200 citations

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses

2004 • 1,164 citations

Gastric Cancer Originating from Bone Marrow-Derived Cells

2004 • 1,146 citations

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

2004 • 1,130 citations

The cytokine handbook

1994 • 1,121 citations

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

2003 • 1,105 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway

2002 • 890 citations

Hepatogastroenterology

2012 • 832 citations

Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion

2003 • 804 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

2003 • 721 citations

Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells

2004 • 629 citations

Receptor for Advanced Glycation End Products (RAGE)-mediated Neurite Outgrowth and Activation of NF-κB Require the Cytoplasmic Domain of the Receptor but Different Downstream Signaling Pathways

1999 • 621 citations

Alkylating DNA damage stimulates a regulated form of necrotic cell death

2004 • 618 citations

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

1985 • 600 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins

2003 • 556 citations

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

1999 • 523 citations

RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages

2005 • 485 citations

Delivery of bioactive molecules into the cell: the Trojan horse approach

2004 • 464 citations

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

2004 • 462 citations

High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization

2004 • 435 citations

Extracellular role of HMGB1 in inflammation and sepsis

2004 • 430 citations

Activation of gene expression in human neutrophils by high mobility group box 1 protein

2003 • 423 citations

Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer.

1989 • 383 citations

In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

1985 • 368 citations

Contributions of High Mobility Group Box Protein in Experimental and Clinical Acute Lung Injury

2004 • 350 citations

Central role of RAGE-dependent neointimal expansion in arterial restenosis

2003 • 342 citations

Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer.

2003 • 332 citations

The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

2004 • 330 citations

Ancestry and diversity of the HMG box superfamily

1993 • 328 citations

High mobility group 1 B‐box mediates activation of human endothelium

2003 • 321 citations

NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1

2005 • 319 citations

Successful treatment of collagen‐induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

2003 • 316 citations

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

2002 • 315 citations

Expression of receptors for advanced glycation end‐products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer

2001 • 313 citations

Central role of RAGE-dependent neointimal expansion in arterial restenosis

2003 • 307 citations

A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate

2004 • 300 citations

Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas

2003 • 295 citations

High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

2002 • 287 citations

Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis.

2002 • 284 citations

RAGE (receptor for advanced glycation end products): a central player in the inflammatory response

2004 • 269 citations

Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions

2004 • 261 citations

HMGB1 contributes to the development of acute lung injury after hemorrhage

2005 • 252 citations

Regulation of monocyte migration by amphoterin (HMGB1)

2004 • 249 citations

Nonhistone Proteins HMG ₁ and HMG ₂ Change the DNA Helical Structure

1978 • 243 citations

30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane.

1991 • 241 citations

Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B

2004 • 239 citations

Purification and Characterization of Mouse Soluble Receptor for Advanced Glycation End Products (sRAGE)

2004 • 215 citations

S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma

2004 • 209 citations

The receptor for advanced glycation end‐products (RAGE) directly binds to ERK by a D‐domain‐like docking site

2003 • 192 citations

The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells

2004 • 189 citations

Receptor for advanced glycation end‐products is a marker of type I lung alveolar cells

2004 • 187 citations

HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and p73-dependent Sequence-specific Transactivation from the Human Bax Gene Promoter

2002 • 183 citations

Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms

2004 • 183 citations

Acetylation of nuclear receptors in cellular growth and apoptosis

2004 • 177 citations

Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice

2004 • 175 citations

Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation

2002 • 170 citations

HMGB1 is a potent trigger of arthritis

2004 • 164 citations

Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer

2003 • 162 citations

Dendritic Cell Subset Ratio in Peripheral Blood Correlates with Successful Withdrawal of Immunosuppression in Liver Transplant Patients

2003 • 161 citations

Addicted to Death

2004 • 157 citations

HMGB-1, A DNA-BINDING PROTEIN WITH CYTOKINE ACTIVITY, INDUCES BRAIN TNF AND IL-6 PRODUCTION, AND MEDIATES ANOREXIA AND TASTE AVERSION

2002 • 149 citations

The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition

2003 • 141 citations

The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose

2003 • 141 citations

RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB

2005 • 137 citations

Direct in vivo gene introduction into rat kidney

1992 • 133 citations

Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects

2003 • 133 citations

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair

2004 • 132 citations

Differential effects between amphoterin and advanced glycation end products on colon cancer cells

2003 • 131 citations

RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways

2004 • 129 citations

Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung.

1998 • 126 citations

ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling

2003 • 126 citations

Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease

2004 • 120 citations

HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro

1999 • 118 citations

Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation.

2003 • 104 citations

The Long Acidic Tail of High Mobility Group Box 1 (HMGB1) Protein Forms an Extended and Flexible Structure That Interacts with Specific Residues within and between the HMG Boxes

2004 • 104 citations

Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1

2004 • 101 citations

S100A7 and the progression of breast cancer

2004 • 99 citations

Blood dendritic cells and DC-poietins in systemic lupus erythematosus

2002 • 98 citations

High mobility group box 1 protein, a cue for stem cell recruitment

2004 • 96 citations

Type II Alveolar Epithelial Cells in Lung Express Receptor for Advanced Glycation End Products (RAGE) Gene

1997 • 96 citations

HMG-1 Stimulates Estrogen Response Element Binding by Estrogen Receptor from Stably Transfected HeLa Cells

1999 • 91 citations

High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression

1997 • 91 citations

Immunological relatedness of high mobility group chromosomal proteins from calf thymus.

1978 • 89 citations

The intracrine hypothesis and intracellular peptide hormone action

2003 • 86 citations

HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain

2003 • 84 citations

High mobility group box protein‐1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity

2004 • 81 citations

TNFα as Therapeutic Target: New Drugs, More Applications

2002 • 81 citations

Variation of HMGB1 expression in breast cancer.

2002 • 78 citations

High-Affinity Binding of Tumor-Suppressor Protein p53 and HMGB1 to Hemicatenated DNA Loops

2004 • 77 citations

Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells.

2004 • 75 citations

CD8+ T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1β and cathepsin D

2001 • 71 citations

P2X₇Receptor and Polykarion Formation

2000 • 69 citations

Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation

2003 • 68 citations

Borna Disease Virus Phosphoprotein Binds a Neurite Outgrowth Factor, Amphoterin/HMG-1

2001 • 60 citations

Condensation of vector DNA by the chromosomal protein HMG1 results in efficient transfection

1988 • 59 citations

The Significance of Changes in High Mobility Group-1 Protein mRNA Expression in Rats After Thermal Injury

2002 • 58 citations

Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK‐1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration

2004 • 56 citations

Physical studies of the nonhistone chromosomal proteins HMG-1 and HMG-2

1976 • 55 citations

Ethyl Pyruvate Provides Durable Protection Against Inflammation-Induced Intestinal Epithelial Barrier Dysfunction

2003 • 52 citations

HMGB1 in the Immunology of Sepsis (Not Septic Shock) and Arthritis

2004 • 52 citations

Specific interaction between H1 histone and high mobility protein HMG1

1994 • 52 citations

Chromosomal Proteins HMGN3a and HMGN3b Regulate the Expression of Glycine Transporter 1

2004 • 50 citations

Recombinant HMG1 Protein Produced in Pichia pastoris: A Nonviral Gene Delivery Agent

1997 • 48 citations

Vesicle Membrane Interactions of Penetratin Analogues

2004 • 48 citations

Regulation of receptor for advanced glycation end products during bleomycin-induced lung injury.

2003 • 47 citations

Rice HMGB1 protein recognizes DNA structures and bends DNA efficiently

2003 • 42 citations

Borna Disease Virus Phosphoprotein Represses p53-Mediated Transcriptional Activity by Interference with HMGB1

2003 • 40 citations

New Stem Cell Center at Cornell

2004 • 40 citations

Cell death, BAX activation, and HMGB1 release during infection with Chlamydia

2004 • 38 citations

Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA

1994 • 37 citations

Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner

2003 • 37 citations

High mobility group box 1 protein as a late-acting mediator of acute lung inflammation.

2004 • 35 citations

Fusigenic Liposome-mediated DNA Transfer into Cardiac Myocytes

1996 • 30 citations

Mutual stabilisation of bacteriophage Mu repressor and histone-like proteins in a nucleoprotein structure

1995 • 25 citations

Estradiol enhanced acetylation of nuclear high mobility group proteins of the uterus of newborn guinea pigs

1989 • 21 citations

Fatal Sequence: The Killer Within

2005 • 18 citations

Differences between HMG1 proteins isolated from normal and tumour cells

1987 • 17 citations

Chromatin subunits elicit species-specific antibodies against nucleoprotein antigenic determinants

1980 • 17 citations

Recombination Hot Spot of Hepatitis B Virus Genome Binds to Members of the HMG Domain Protein Family and the Y Box Binding Protein Family; Implication of These Proteins in Genomic Instability

2001 • 16 citations

Synapsis of Recombination Signal Sequences Located in cis and DNA Underwinding in V(D)J Recombination

2004 • 16 citations

Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations

1995 • 14 citations

Conformational Difference in HMGB1 Proteins of Human Neutrophils and Lymphocytes Revealed by Epitope Mapping of a Monoclonal Antibody

2004 • 11 citations

Expression pattern of the HMGB1 gene in sarcomas of the dog.

2004 • 10 citations

HMGB-1

2003 • 7 citations

Fatal Sequence—The Killer Within

2005 • 6 citations

Transfection by DNA-nuclear protein HMG1 complexes: raising of efficiency and role of DNA topology.

1990 • 6 citations

Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1

2004 • 5 citations

HMG-1 as regulatory trans-acting protein in the acute phase-induced expression of the rat liver haptoglobin gene.

2001 • 5 citations

[High mobility group box-1 protein activates Janus kinase-signal transducer and activator of transcription pathway in rat peritoneal macrophages].

2004 • 2 citations