Processing without proteolytic cleavage is required for recognition of insulin by T cells

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.

1981 • 391 citations

The specific site of tunicamycin inhibition in the formation of dolichol‐bound N‐acetylglucosamine derivatives

1976 • 362 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases.

1981 • 208 citations

Requirements for the processing of antigens by antigen-presenting B cells. I. Functional comparison of B cell tumors and macrophages.

1982 • 201 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Cerulenin blocks fatty acid acylation of glycoproteins and inhibits vesicular stomatitis and Sindbis virus particle formation.

1982 • 128 citations

Chloroquine affects biosynthesis of Ia molecules by inhibiting dissociation of invariant (gamma) chains from alpha-beta dimers in B cells.

1985 • 123 citations

MHC-Antigen Interaction: What Does the T Cell Receptor See?

1989 • 102 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells.

1986 • 74 citations

CHLOROQUINE AS A PROBE FOR ANTIGEN PROCESSING BY ACCESSORY CELLS1

1982 • 61 citations

Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs.

1981 • 53 citations

Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells.

1987 • 46 citations

Cerulenin is a potent inhibitor of antigen processing by antigen-presenting cells.

1987 • 31 citations

Processing and presentation of insulin. II. Evidence for intracellular, plasma membrane-associated and extracellular degradation of human insulin by antigen-presenting B cells.

1989 • 24 citations

Development of T cell clones reactive to two defined restriction elements in conjunction with two defined epitopes of antigen

1985 • 23 citations

Flexibility of the T cell repertoire. Self tolerance causes a shift of T cell receptor gene usage in response to insulin.

1990 • 22 citations

Immunologically discrete conformation isomers of I‐A locus‐equivalent class II molecules detected in Lewis rats

1985 • 21 citations

Antigen‐Ia interaction and the proteolytic processing of antigen: the structure of the antigen determines its restriction to the A or E molecule of the major histocompatibility complex

1986 • 21 citations

Processing Requirements for the Recognition of Insulin Fragments by Murine T cells

1988 • 16 citations

Pathways of Processing of Insulin by Antigen‐Presenting Cells

1988 • 15 citations

Characterization of Lymphokine-mediated Activation of Macrophages for Antigen Presentation: Studies with Long-Term Cultured Bone Marrow-derived Macrophages and Cloned T Cells

1984 • 12 citations

The specificity of the interaction between the agretope of an antigen and an Ia-molecule can depend on the T cell clonotype

1988 • 11 citations

Cell-mediated processing and presentation of T cell antigenic determinants

1989 • 4 citations

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