Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme.

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway

1990 • 972 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

1988 • 434 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.

1984 • 272 citations

Class II MHC molecules can use the endogenous pathway of antigen presentation

1990 • 271 citations

Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence

1986 • 242 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells.

1989 • 228 citations

HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells

1989 • 201 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.

1988 • 180 citations

Signals and salvage sequences

1987 • 121 citations

Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells

1989 • 113 citations

Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule.

1990 • 109 citations

Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules

1989 • 94 citations

Ligand thresholds at different stages of T cell development

1990 • 84 citations

Inhibition by brefeldin A of presentation of exogenous protein antigens to MHC class II-restricted T cells

1990 • 74 citations

Complex regulation of class II gene expression: analysis with class II mutant cell lines.

1985 • 67 citations

Class II major histocompatibility complex-restricted T cells specific for a virion structural protein that do not recognize exogenous influenza virus. Evidence that presentation of labile T cell determinants is favored by endogenous antigen synthesis.

1989 • 53 citations

Anchor sequence-dependent endogenous processing of human immunodeficiency virus 1 envelope glycoprotein gp160 for CD4+ T cell recognition.

1990 • 49 citations

T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas.

1989 • 48 citations

The role of the endoplasmic reticulum in antigen processing. N-glycosylation of influenza hemagglutinin abrogates CD4+ cytotoxic T cell recognition of endogenously processed antigen.

1990 • 35 citations

Questions of presentation

1990 • 31 citations

Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes.

1989 • 26 citations

The extracellular domains of MHC class II molecules determine their processing requirements for antigen presentation.

1990 • 16 citations