CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

2006 • 2,903 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2008 • 1,801 citations

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

2008 • 1,788 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Pathogenesis and therapy of psoriasis

2007 • 1,652 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

2008 • 1,624 citations

Chemokines and disease

2001 • 1,371 citations

IL-22 Increases the Innate Immunity of Tissues

2004 • 1,330 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

2009 • 1,296 citations

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

2008 • 1,268 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

2008 • 1,188 citations

The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

2000 • 1,077 citations

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

2007 • 1,070 citations

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

2009 • 1,031 citations

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

2008 • 1,030 citations

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

2008 • 1,020 citations

Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial

2005 • 1,016 citations

Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

2001 • 913 citations

Psoriasis

2005 • 904 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

2008 • 897 citations

Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

2004 • 873 citations

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

2007 • 870 citations

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

2008 • 796 citations

A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis

2007 • 771 citations

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

2008 • 750 citations

The Vast Majority of CLA+ T Cells Are Resident in Normal Skin

2006 • 741 citations

A global phase III randomized controlled trial of etanercept in psoriasis: safety, efficacy, and effect of dose reduction

2005 • 686 citations

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

2006 • 662 citations

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

2007 • 654 citations

Th17: the third member of the effector T cell trilogy

2007 • 642 citations

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

2001 • 549 citations

IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation

2008 • 539 citations

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

2000 • 533 citations

Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

2008 • 521 citations

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

2008 • 520 citations

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

2008 • 509 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

2007 • 478 citations

Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

2004 • 474 citations

A Randomized Trial of Etanercept as Monotherapy for Psoriasis

2003 • 470 citations

Transcriptional regulation of Th17 cell differentiation

2007 • 469 citations

Getting under the skin: the immunogenetics of psoriasis

2005 • 465 citations

Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

2004 • 453 citations

Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

2005 • 446 citations

In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin

2006 • 442 citations

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis

2007 • 413 citations

CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

1999 • 404 citations

Pathophysiology of psoriasis: Recent advances on IL-23 and Th17 cytokines

2007 • 370 citations

Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo

2006 • 366 citations

An overview of IL-17 function and signaling

2008 • 358 citations

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

2008 • 349 citations

CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α

1999 • 345 citations

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

2004 • 321 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

A role for T cell-derived interleukin 22 in psoriatic skin inflammation

2007 • 283 citations

Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis

2008 • 266 citations

CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

2006 • 245 citations

Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors.

1988 • 221 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

Reviews Of Anti‐infective Agents: Maraviroc: The First of a New Class of Antiretroviral Agents

2008 • 206 citations

Interleukin-17 in inflammatory skin disorders

2007 • 178 citations

T-Helper 17 Cells in Psoriatic Plaques and Additional Genetic Links between IL-23 and Psoriasis

2008 • 163 citations

IL-23 Production by Cosecretion of Endogenous p19 and Transgenic p40 in Keratin 14/p40 Transgenic Mice: Evidence for Enhanced Cutaneous Immunity

2003 • 130 citations

Protective Immunity to Systemic Infection with AttenuatedSalmonella entericaserovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

2008 • 118 citations

CC Chemokine Receptor 6 Expression by B Lymphocytes Is Essential for the Development of Isolated Lymphoid Follicles

2007 • 91 citations

Expression of the C-C chemokine MIP-3α/CCL20 in human epidermis with impaired permeability barrier function

2002 • 91 citations

CCR6 has a non‐redundant role in the development of inflammatory bowel disease

2003 • 88 citations

CCR6 regulates CD4+ T-cell–mediated acute graft-versus-host disease responses

2005 • 87 citations

Blockade of CD11a by Efalizumab in Psoriasis Patients Induces a Unique State of T-Cell Hyporesponsiveness

2008 • 58 citations

Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris

2004 • 58 citations

Lymphocyte trafficking to inflamed skin – molecular mechanisms and implications for therapeutic target molecules

2005 • 49 citations

Inflammatory Skin Disease in K14/p40 Transgenic Mice: Evidence for Interleukin-12-Like Activities of p40

2001 • 49 citations

Essential Role of CCR6 in Directing Activated T Cells to the Skin during Contact Hypersensitivity

2007 • 34 citations